Model Overview
Contents
List of Model Reactions
*1 Reactions taking place only in the scenario which includes the activating complex
*2 Reactions taking place only in the scenario which includes the antisense RNA interactions
Reactions |
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*1
*1 *1 *1 *1 *1
*1 *2
*1 *2
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Parameters for model reactions
Reaction | Parameter | Value | Units | Distribution
Mode |
Confidence
Interval Factor |
Location
parameter (μ) |
Scale
parameter (σ) |
---|---|---|---|---|---|---|---|
Binding of R2 to OR operator | 0.005−5.8 | 0.299 | 46.7 | 0.45876 | 1.2899 | ||
0.09−0.846 | 0.489 | 3.9 | −0.36413 | 0.59272 | |||
Binding of R2 to OA operator | 0.005−5.8 | 0.299 | 46.7 | 0.45876 | 1.2899 | ||
0.09−0.846 | 0.489 | 3.9 | −0.36413 | 0.59272 | |||
Binding of R2 to A | 100.4 | 15.184 | 1.4621 | ||||
341 | 12.4141 | 1.7134 | |||||
Binding of R2 to C | 1 | 100000 | 7.934 | 2.7911 | |||
0.82 | 59545 | 6.4365 | 2.5767 | ||||
Binding of A-R2 to OA' operator | 0.005−5.8 | 0.299 | 46.7 | 0.45876 | 1.2899 | ||
0.09−0.846 | 0.489 | 3.9 | −0.36413 | 0.59272 | |||
Synthesis of C | 0.0011−0.01 | 0.0033 | 3 | −5.4531 | 0.49744 | ||
Transcription of r | 0.16−8.24 | 0.8346 | 12.6 | 0.73383 | 0.95636 | ||
18.2−33 | 20.4 | 1.74 | 3.0886 | 0.2686 | |||
0.0518-14.5 | 0.867 | 16.74 | 0.92634 | 1.034 | |||
Transcription of a | 0.11−5.65 | 0.57 | 12.5 | 0.354505 | 0.95491 | ||
0.039-8.82 | 0.587 | 15 | 0.47762 | 1.0048 | |||
Antisense interaction between r and a | 0.4−89 | 7.8 | 52.8 | 3.7933 | 1.3186 | ||
0.006−6 | 0.22 | 23.2 | −0.24716 | 1.1192 | |||
Translation of R | 0.165−5.86 | 0.74 | 10.3 | 0.50964 | 0.89756 | ||
Translation of A | 0.11−4 | 0.51 | 10.3 | 0.13413 | 0.89936 | ||
Formation of homo-dimer R2 | 2.58-42.9 | 30 | 30 | 4.8018 | 1.1835 | ||
0.144-51.2 | 2 | 30 | 2.094 | 1.1835 | |||
Degradation of r | 0.03−0.365 | 0.14 | 4.24 | −1.5762 | 0.62077 | ||
Degradation of R | 2.5 | −6.2752 | 0.4285 | ||||
Degradation of R2 | 2.5 | −6.2752 | 0.4285 | ||||
Degradation of a | 0.03−0.365 | 0.14 | 4.24 | −1.5762 | 0.62077 | ||
Degradation of A | 2.5 | −6.2752 | 0.4285 | ||||
Degradation of C | 25.8 | −4.4205 | 1.1461 | ||||
Degradation of C2-R2 | 2.5 | −6.2752 | 0.4285 | ||||
Degradation of A-R2 | 2.5 | −6.2752 | 0.4285 | ||||
Degradation of r-a | 0.35−69.3 | 0.739 | 200.4 | 2.2813 | 1.6074 | ||
Diffusion of C and Ce | 0.1−24 | 2.8 | 18.2 | 2.1457 | 1.0564 | ||
Degradation of Ce | 25.8 | −4.4205 | 1.1461 | ||||
Cellular growth | Failed to parse (PNG conversion failed; check for correct installation of latex and dvipng (or dvips + gs + convert)): μ | 0.0004−0.0107 | 0.0022 | 7.5 | −5.4517 | 0.80808 |
Parameters for cell colony growth
Parameter | Value | Units |
---|---|---|
Failed to parse (PNG conversion failed; check for correct installation of latex and dvipng (or dvips + gs + convert)): τ | ||
Failed to parse (PNG conversion failed; check for correct installation of latex and dvipng (or dvips + gs + convert)): λ | ||
Initial concentrations of species
Species | Initial concentration | Units | Compartment |
---|---|---|---|
OR | 0.9592 | Cell | |
OA | 0.9592 | Cell | |
OR-R2 | 0 | Cell | |
OA-R2 | 0 | Cell | |
OA'-AR2 | 0 | Cell | |
r | 0 | Cell | |
a | 0 | Cell | |
r-a | 0 | Cell | |
R | 0 | Cell | |
R2 | 0 | Cell | |
A | 0 | Cell | |
C | 0 | Cell | |
AR2 | 0 | Cell | |
C2R2 | 0 | Cell | |
Ce | 0 | Environment |