Difference between revisions of "Degradation Pathways"

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[[Welcome to the In-Silico Model of Cutaneous Lipids Wiki | Return to overview]]
 
[[Welcome to the In-Silico Model of Cutaneous Lipids Wiki | Return to overview]]
  
Upon being transported out of the cell, the eicosanoids accumulate in the interstitial fluid, which for simplicity is referred to as the extracellular compartment in the model. A decay constant was included for each extracellular metabolite to represent degradation. To describe the breaking down of metabolites an irreversible mass action rate law was used for reactions 43-64. The half life of each eicosanoid was initially assumed as 24 hours, but will be made metabolite specific when all of the values have been collected.  
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To account for the decay in metabolite concentration over time, there are 46 decay reactions in this network. In these reactions, the product mass is pooled together under the term “Miscellaneous metabolites”. This is a collective term which refers to metabolites which are no longer of interest to this work, for example they are exported to the systemic circulation or undergo degradation. To account for the different rate of metabolite decay in the intracellular and extracellular compartments, each metabolite has two decay reactions which are governed by independent parameters.
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Pseudo-first order reactions.
  
Pseudo-first order reactions.
 
 
<math> k = ln(2)/t(0.5) </math>
 
<math> k = ln(2)/t(0.5) </math>
  

Revision as of 09:50, 17 May 2019

Return to overview

To account for the decay in metabolite concentration over time, there are 46 decay reactions in this network. In these reactions, the product mass is pooled together under the term “Miscellaneous metabolites”. This is a collective term which refers to metabolites which are no longer of interest to this work, for example they are exported to the systemic circulation or undergo degradation. To account for the different rate of metabolite decay in the intracellular and extracellular compartments, each metabolite has two decay reactions which are governed by independent parameters. Pseudo-first order reactions.

 k = ln(2)/t(0.5)


References