Difference between revisions of "Degradation Pathways"
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* [[Decay of 3,4-Dihydro-15-Keto-PGE2 to ex3,4-Dihydro-15-Keto-PGE2 |Decay of 13,14-dihydro-15-keto-PGE<sub>2</sub>/ex13,14-dihydro-15-keto-PGE<sub>2</sub> (R71/80)]] | * [[Decay of 3,4-Dihydro-15-Keto-PGE2 to ex3,4-Dihydro-15-Keto-PGE2 |Decay of 13,14-dihydro-15-keto-PGE<sub>2</sub>/ex13,14-dihydro-15-keto-PGE<sub>2</sub> (R71/80)]] | ||
* [[Decay of 5-Oxo-ETE to ex5-Oxo-ETE |Decay of 5-oxo-ETE/ex5-oxo-ETE (R54/91) ]] | * [[Decay of 5-Oxo-ETE to ex5-Oxo-ETE |Decay of 5-oxo-ETE/ex5-oxo-ETE (R54/91) ]] | ||
| − | + | * [[Decay of LTB4 to exLTB4 |Decay of LTB<sub>4</sub>/exLTB<sub>4</sub> (R56/93) ]] | |
* [[Decay of LTC4 to exLTC4 |Decay of LTC<sub>4</sub>/exLTC<sub>4</sub> (R57/94) ]] | * [[Decay of LTC4 to exLTC4 |Decay of LTC<sub>4</sub>/exLTC<sub>4</sub> (R57/94) ]] | ||
* [[Decay of LTA4 to exLTA4 |Decay of LTA<sub>4</sub>/exLTA<sub>4</sub> (R58/92) ]] | * [[Decay of LTA4 to exLTA4 |Decay of LTA<sub>4</sub>/exLTA<sub>4</sub> (R58/92) ]] | ||
Revision as of 08:16, 17 May 2019
Upon being transported out of the cell, the eicosanoids accumulate in the interstitial fluid, which for simplicity is referred to as the extracellular compartment in the model. A decay constant was included for each extracellular metabolite to represent degradation. To describe the breaking down of metabolites an irreversible mass action rate law was used for reactions 43-64. The half life of each eicosanoid was initially assumed as 24 hours, but will be made metabolite specific when all of the values have been collected.
Pseudo-first order reactions.
