Difference between revisions of "Degradation Pathways"
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| − | * [[Decay of | + | * [[Decay of AA to exAA|Decay of AA/exAA (R64/72) ]] |
| − | * [[Decay of | + | * [[Decay of PGI2 to exPGI2 |Decay of PGI<sub>2</sub>/exPGI<sub>2</sub> (R48/77) ]] |
| − | * [[Decay of | + | * [[Decay of PGE2 to exPGE2 |Decay of PGE<sub>2</sub>/exPGE<sub>2</sub> (R49/76) ]] |
| − | * [[Decay of | + | * [[Decay of PGF2a/exPGF2a |Decay of PGF<sub>2a</sub>/exPGF<sub>2a</sub> (R44/74) ]] |
| − | * [[Decay of | + | * [[Decay of PGH2 to exPGH2 |Decay of PGH<sub>2</sub>/exPGH<sub>2</sub> (R53/73) ]] |
| − | * [[Decay of | + | * [[Decay of PGD2 to exPGD2 |Decay of PGD<sub>2</sub>/exPGD<sub>2</sub> (R52/78) ]] |
| − | * [[Decay of | + | * [[Decay of PGJ2 to exPGJ2 |Decay of PGJ<sub>2</sub>/exPGJ<sub>2</sub> (R51/83) ]] |
| − | * [[Decay of | + | * [[Decay of TXB2/exTXB2 |Decay of TXB<sub>2</sub>/exTXB<sub>2</sub> (R45/81) ]] |
| − | * [[Decay of | + | * [[Decay of TXA2 to exTXA2 |Decay of TXA<sub>2</sub>/exTXA<sub>2</sub> (R46/75) ]] |
| − | * [[Decay of | + | * [[Decay of K6PGF2a to exK6PGF2a |Decay of 6-keto-PGF<sub>1a</sub>/ex6-keto-PGF<sub>1a</sub> (R47/82)]] |
| − | * [[Decay of | + | * [[Decay of D15PGJ2 to exD15PGJ2 |Decay of 15-deoxy-PGJ<sub>2</sub>/ex15-deoxy-PGJ<sub>2</sub> (R50/84) ]] |
| − | * [[Decay of | + | * [[Decay of 15-Keto-PGE2 to ex15-Keto-PGE2 |Decay of 15-keto-PGE<sub>2</sub>/ex15-keto-PGE<sub>2</sub> (R68/79)]] |
| − | * [[Decay of | + | * [[Decay of 3,4-Dihydro-15-Keto-PGE2 to ex3,4-Dihydro-15-Keto-PGE2 |Decay of 13,14-dihydro-15-keto-PGE<sub>2</sub>/ex13,14-dihydro-15-keto-PGE<sub>2</sub> (R71/80)]] |
| − | * [[Decay of | + | * [[Decay of 5-Oxo-ETE to ex5-Oxo-ETE |Decay of 5-oxo-ETE/ex5-oxo-ETE (R54/91) ]] |
| − | * [[Decay of | + | * [[Decay of LTB4 to exLTB4 |Decay of LTB<sub>4</sub>/exLTB<sub>4</sub> (R56/93) ]] |
| − | * [[Decay of 12-HPETE to ex12-HPETE |Decay of 12-HPETE/ex12-HPETE ]] | + | * [[Decay of LTC4 to exLTC4 |Decay of LTC<sub>4</sub>/exLTC<sub>4</sub> (R57/94) ]] |
| − | * [[Decay of 15-HPETE to ex15-HPETE |Decay of 15-HPETE/ex15-HPETE ]] | + | * [[Decay of LTA4 to exLTA4 |Decay of LTA<sub>4</sub>/exLTA<sub>4</sub> (R58/92) ]] |
| − | * [[Decay of 5-HPETE to ex5-HPETE |Decay of 5-HPETE/ex5-HPETE ]] | + | * [[Decay of 12-HPETE to ex12-HPETE |Decay of 12-HPETE/ex12-HPETE (R63/86) ]] |
| − | * [[Decay of 5-HETE to ex5-HETE |Decay of 5-HETE/ex5-HETE | + | * [[Decay of 15-HPETE to ex15-HPETE |Decay of 15-HPETE/ex15-HPETE (R61/85)]] |
| − | + | * [[Decay of 5-HPETE to ex5-HPETE |Decay of 5-HPETE/ex5-HPETE (R59/87) ]] | |
| − | + | * [[Decay of 5-HETE to ex5-HETE |Decay of 5-HETE/ex5-HETE (R55/90) ]] | |
| − | * [[Decay of 15- | + | * [[Decay of 15-HETE to ex15-HETE |Decay of 15-HETE/ex15-HETE (R60/88) ]] |
| − | * [[Decay of | + | * [[Decay of 12-HETE to ex12-HETE |Decay of 12-HETE/ex12-HETE (R62/89) ]] |
|} | |} | ||
Revision as of 08:15, 17 May 2019
Upon being transported out of the cell, the eicosanoids accumulate in the interstitial fluid, which for simplicity is referred to as the extracellular compartment in the model. A decay constant was included for each extracellular metabolite to represent degradation. To describe the breaking down of metabolites an irreversible mass action rate law was used for reactions 43-64. The half life of each eicosanoid was initially assumed as 24 hours, but will be made metabolite specific when all of the values have been collected.
Pseudo-first order reactions.
