Literature Parameters

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Enzyme Parameters

Reaction Enzyme E.C. Parameter Value Unit Species Reference
Transformation of FA to AA cPLA2a 3.1.1.4 Failed to parse (Cannot store math image on filesystem.): Km 2.60E+00 mM Human PMN [1]
Failed to parse (Cannot store math image on filesystem.): Kcat 3600 Failed to parse (Cannot store math image on filesystem.): min{-1}
Failed to parse (Cannot store math image on filesystem.): Km 2.50E-03 mM Mouse Fibroblasts Cytosolic PLA2 [2]
Failed to parse (Cannot store math image on filesystem.): (Vmax)^{max} 2.00E-07 Failed to parse (Cannot store math image on filesystem.): mmol/min/mg
Failed to parse (Cannot store math image on filesystem.): (Vmax)^{min} 1.00E-07 Failed to parse (Cannot store math image on filesystem.): mmol/min/mg
Failed to parse (Cannot store math image on filesystem.): Km 5.00E-02 mM Human Recombinant PLA2 (Phosphatidylcholine as the substrate) [3]
Failed to parse (Cannot store math image on filesystem.): Vmax 3.00E-03 Failed to parse (Cannot store math image on filesystem.): mmol/min/mg
Failed to parse (Cannot store math image on filesystem.): Km 2.00E-02 mM Human Recombinant PLA2 (Phosphatidylethanolamine as the substrate) [3]
Failed to parse (Cannot store math image on filesystem.): Vmax 7.00E-02 Failed to parse (Cannot store math image on filesystem.): mmol/min/mg
Failed to parse (Cannot store math image on filesystem.): Km 4.13E-01 ± 2.80E-02 mM Rat PMN Neutrophils [4]
Transformation of AA to PGH2 COX-2 1.14.99.1 Failed to parse (Cannot store math image on filesystem.): Km 3.30E-02 mM Human PMN [1]
Failed to parse (Cannot store math image on filesystem.): Kcat 1000 min^{-1}
Failed to parse (Cannot store math image on filesystem.): Vmax 8.13E-05 Failed to parse (Cannot store math image on filesystem.): mmol/min/mg Human [5]
Failed to parse (Cannot store math image on filesystem.): Km 1.62E-02 mM
Transformation of PGH2 to PGF2α PGFS 1.1.1.188 Failed to parse (Cannot store math image on filesystem.): Km 1.90E-03 ± 1.5E-03 mM Human Placental Aldose Reductase (AKR1B1) [6]
Failed to parse (Cannot store math image on filesystem.): Vmax 2.60E-05 ± 6.20E-06 Failed to parse (Cannot store math image on filesystem.): mmol/min/mg
Failed to parse (Cannot store math image on filesystem.): Km 1.80E-02 mM Human Lung PGF2a Synthase (AKR1C3) [6]
Failed to parse (Cannot store math image on filesystem.): Vmax 4.00E-06 Failed to parse (Cannot store math image on filesystem.): mmol/min/mg
Transformation of PGH2 to TXA2 TXAS 5.3.99.5 Failed to parse (Cannot store math image on filesystem.): Km 4.00E-03 mM Human PMN [1]
Failed to parse (Cannot store math image on filesystem.): Kcat 1599 Failed to parse (Cannot store math image on filesystem.): min{-1}
Failed to parse (Cannot store math image on filesystem.): Km 4.00E-03 mM Platelet Free Human Monocyte [7]
Failed to parse (Cannot store math image on filesystem.): Km 1.00E-02 mM Human Thromboxane Synthase [8]
Failed to parse (Cannot store math image on filesystem.): Km 2.20E-02 mM Human Wild-Type TXAS [9]
Failed to parse (Cannot store math image on filesystem.): Vmax 1.60E-05 Failed to parse (Cannot store math image on filesystem.): mmol/min/mg
Transformation of PGH2 to PGI2 PGIS 5.3.99.4 Failed to parse (Cannot store math image on filesystem.): Km 1.33E-02 ± 1.40E-03 mM Human PGIS [10]
Failed to parse (Cannot store math image on filesystem.): Km 9.00E-03 ± 5.00E-03 mM Bovine Endothelial Cells [11]
Failed to parse (Cannot store math image on filesystem.): Vmax 2.00E-03 ± 5.00E-04 Failed to parse (Cannot store math image on filesystem.): mmol/min/mg
Transformation of PGH2 to PGD2 PGDS 5.3.99.2 Failed to parse (Cannot store math image on filesystem.): Km 4.00E-03 mM Human Cerebrospinal Fluid [12]
Failed to parse (Cannot store math image on filesystem.): Km 4.00E-03 mM Human Wild Type Enzyme [13]
Failed to parse (Cannot store math image on filesystem.): Vmax 9.27E-03 Failed to parse (Cannot store math image on filesystem.): mmol/min/mg
Transformation of PGH2 to PGE2 PGES 5.3.99.3 Failed to parse (Cannot store math image on filesystem.): Km 1.6E-01 ± 4.00E-03 mM Human Synovial Tissue [14]
Failed to parse (Cannot store math image on filesystem.): Km 2.15E-01 mM Human Wild Type Enzyme [15]
Failed to parse (Cannot store math image on filesystem.): Vmax 1.70E-01 ± 2.00E-02 Failed to parse (Cannot store math image on filesystem.): mmol/min/mg Human Recombinant His6-mPGES-1 [16]
Failed to parse (Cannot store math image on filesystem.): Km 6.66E-02 mM Human cPGES [17]
Failed to parse (Cannot store math image on filesystem.): Vmax 2.00E-03 Failed to parse (Cannot store math image on filesystem.): mmol/min/mg
Failed to parse (Cannot store math image on filesystem.): Km 1.49E-02 mM Human cPGES, casein kinase II and Hsp90 [17]
Failed to parse (Cannot store math image on filesystem.): Vmax 2.50E-03 Failed to parse (Cannot store math image on filesystem.): mmol/min/mg
Transformation of AA to 5-HPETE 5-LOX 1.13.11.34 Failed to parse (Cannot store math image on filesystem.): Km 5.10E-03 mM Human Recombinant 5-Lipoxygenase [18]
Failed to parse (Cannot store math image on filesystem.): Km 1.20E-02 mM Human PMN Leukocyte [19]
Failed to parse (Cannot store math image on filesystem.): Km 6.31E-02 mM Human Polymorphonuclear Leukocytes [20]
Failed to parse (Cannot store math image on filesystem.): Vmax 5.30E-06 Failed to parse (Cannot store math image on filesystem.): mmol/min/mg
Transformation of 5-HPETE to LTA4 5-LOX & FLAP 1.13.11.34 Failed to parse (Cannot store math image on filesystem.): Km X Failed to parse (Cannot store math image on filesystem.): μM Y A
Failed to parse (Cannot store math image on filesystem.): Kcat Z min^{-1}
Transformation of 5-HPETE to 5-HETE  ? D Failed to parse (Cannot store math image on filesystem.): Km X Failed to parse (Cannot store math image on filesystem.): μM Y A
Failed to parse (Cannot store math image on filesystem.): Kcat Z min^{-1}
Transformation of AA to 15-HPETE 15-LOX 1.13.11.33 Failed to parse (Cannot store math image on filesystem.): Km 3.70E-03 ± 3.00E-04 mM Human Epithelium [21]
Failed to parse (Cannot store math image on filesystem.): Kcat 9.93 ± 0.28 Failed to parse (Cannot store math image on filesystem.): s^{-1}
Failed to parse (Cannot store math image on filesystem.): Km 5.00E-03 mM Human Reticulocyte [22]
Failed to parse (Cannot store math image on filesystem.): Km 1.06E-02 mM Human Keratinocyte [23]
Failed to parse (Cannot store math image on filesystem.): Km 1.17E-02 ± 9.00E-04 mM Human Wildtype 15-Lipoxygenase [24]
Failed to parse (Cannot store math image on filesystem.): Vmax ***7.30E-07± 2.00E-07 Failed to parse (Cannot store math image on filesystem.): mmol/min/μg
Transformation of 15-HPETE to 15-HETE

Transformation of 12-HPETE to 12-HETE

PHGPx 1.11.1.9 Failed to parse (Cannot store math image on filesystem.): Km 3.00E-01 mM Human Bioimprited Enzyme [25]
Failed to parse (Cannot store math image on filesystem.): Kcat 1170 ± 50 min^{-1}
Failed to parse (Cannot store math image on filesystem.): Km 11.1 ± 2.90E-01 mM Human Wild Type Enzyme (Se-hGSTZ1-1) [26]
Failed to parse (Cannot store math image on filesystem.): Kcat 24500 ± 150 min^{-1}
Failed to parse (Cannot store math image on filesystem.): Vmax 5.11E-01 Failed to parse (Cannot store math image on filesystem.): mmol/mg/min Rat liver cytosol Se-GSH Px (15-HPETE as the substrate) [27]
Failed to parse (Cannot store math image on filesystem.): Km 4.00E-03 mM Rat liver cytosol Se-GSH Px (5-HPETE as the substrate) [27]
Failed to parse (Cannot store math image on filesystem.): Vmax 6.50E-05 Failed to parse (Cannot store math image on filesystem.): mmol/mg/min
Transformation of AA to 12-HPETE 12-LOX 1.13.11.31 Failed to parse (Cannot store math image on filesystem.): Km 7.20E-03 mM Human Platelet [28]
Failed to parse (Cannot store math image on filesystem.): Km 8.00E-02 mM Human Platelet [29]
Failed to parse (Cannot store math image on filesystem.): Km 1.00E-02 mM Recombinant Histidine-Tagged Human Platelet 12-Lipoxygenase [30]
Failed to parse (Cannot store math image on filesystem.): Vmax 3.00E-03 Failed to parse (Cannot store math image on filesystem.): mmol/min/mg
Failed to parse (Cannot store math image on filesystem.): Km 7.90E-03 ± 8.00E-04 mM Human Platelet 12-Lipoxygenase [31]
Failed to parse (Cannot store math image on filesystem.): Vmax 2.45E-05 ± 2.50E-06 Failed to parse (Cannot store math image on filesystem.): nmol/min/mg

Non-Enzyme Catalysed Reaction Parameters

Reaction Parameter Value Unit Species Reference
Transformation of TXA2 to TXB2 Failed to parse (Cannot store math image on filesystem.): Kf X Failed to parse (Cannot store math image on filesystem.): μM Y A
Failed to parse (Cannot store math image on filesystem.): Kr Z min^{-1}
Transformation of PGI2 to 6-Keto-PGF2A Failed to parse (Cannot store math image on filesystem.): Kf X Failed to parse (Cannot store math image on filesystem.): μM Y A
Failed to parse (Cannot store math image on filesystem.): Kr Z min^{-1}
Transformation of PGD2 to PGJ2 Failed to parse (Cannot store math image on filesystem.): Kf X Failed to parse (Cannot store math image on filesystem.): μM Y A
Failed to parse (Cannot store math image on filesystem.): Kr Z min^{-1}
Transformation of PGJ2 to 15-Deoxy-PGJ2 Failed to parse (Cannot store math image on filesystem.): Kf X Failed to parse (Cannot store math image on filesystem.): μM Y A
Failed to parse (Cannot store math image on filesystem.): Kr Z min^{-1}
Transformation of 5-HETE to 5-Oxo-ETE Failed to parse (Cannot store math image on filesystem.): Kf X Failed to parse (Cannot store math image on filesystem.): μM Y A
Failed to parse (Cannot store math image on filesystem.): Kr Z min^{-1}
Transformation of LTA4 to LTB4 Failed to parse (Cannot store math image on filesystem.): Kf X Failed to parse (Cannot store math image on filesystem.): μM Y A
Failed to parse (Cannot store math image on filesystem.): Kr Z min^{-1}

References

  1. ↑ 1.0 1.1 1.2 Yang K. “Finding multiple target optimal intervention in disease-related molecular network.” Mol Syst Biol 2008, (4):228
  2. ↑ Spaargaren M. “Characterization and identification of an epidermal-growth-factor-activated phospholipase A2.” Biochem J. 1992 Oct 1; 287(Pt 1): 37–43.
  3. ↑ 3.0 3.1 Kawauchi Y. “Preparation and characterization of human rheumatoid arthritic synovial fluid phospholipase A2 produced by recombinant baculovirus-infected insect cells.” J Biochem. 1994 Jul;116(1):81-7.
  4. ↑ Kawauchi Y. “Changes in kinetic properties of cytosolic phospholipase A2 in activated rat neutrophils.” Adv Exp Med Biol. 1997;433:439-42.
  5. ↑ S.F. Kim Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science 2005,310(5756):1966-70)
  6. ↑ 6.0 6.1 Z. Kabututu, M. Manin, Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1, 1B3 and 1B7. J Biochem 2009,145(2):161-8)
  7. ↑ M. Orlandi, G. Bartolini, Thromboxane A2 synthase activity in platelet free human monocytes. Biochim Biophys Acta. 1994 Dec 8;1215(3):285-90.
  8. ↑ R. Nusing, S. Schneider-Voss and V. Ullrich, Immunoaffinity purification of human thromboxane synthase. Arch Biochem Biophys. 1990 Aug 1;280(2):325-30.
  9. ↑ Hecker M. On the mechanism of prostacyclin and thromboxane A2 biosynthesis.J Biol Chem. 1989 Jan 5;264(1):141-50.
  10. ↑ H. C. Yeh, P. Y. Hsu, Characterization of heme environment and mechanism of peroxide bond cleavage in human prostacyclin synthase. Biochim Biophys Acta. 2005 Dec 30;1738(1-3):121-32.
  11. ↑ Hara S. , Isolation and molecular cloning of prostacyclin synthase from bovine endothelial cells. J Biol Chem. 1994 Aug 5;269(31):19897-903.
  12. ↑ Watanabe K. , "Structure-function analysis of human l-prostaglandin D synthase bound with fatty acid molecules. Biochem Biophys Res Commun. 1994 Sep 15;203(2):1110-6.
  13. ↑ Zhou Y. , "Identification of beta-trace as prostaglandin D synthase. FASEB J. 2010 Dec;24(12):4668-77. doi: 10.1096/fj.10-164863. Epub 2010 Jul 28.
  14. ↑ Pettersson P. , "Identification of beta-trace as prostaglandin D synthase. FASEB J. 2010 Dec;24(12):4668-77. doi: 10.1096/fj.10-164863. Epub 2010 Jul 28.
  15. ↑ Hamza A. , "Understanding microscopic binding of human microsomal prostaglandin E synthase-1 (mPGES-1) trimer with substrate PGH2 and cofactor GSH: insights from computational alanine scanning and site-directed mutagenesis. J Phys Chem B. 2010 Apr 29;114(16):5605-16. doi: 10.1021/jp100668y.
  16. ↑ Thoren S. , "Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination. J Biol Chem. 2003 Jun 20;278(25):22199-209. Epub 2003 Apr 2.
  17. ↑ 17.0 17.1 Kobayashi T. , "Regulation of cytosolic prostaglandin E synthase by phosphorylation. Biochem J. 2004 Jul 1;381(Pt 1):59-69.
  18. ↑ Shirumalla R. K. “RBx 7,796: A novel inhibitor of 5-lipoxygenase.” Inflamm Res. 2006 Dec ; 55 (12) : 517-27.
  19. ↑ Soberman R. J. "5- and 15(omega-6)-lipoxygenases from human polymorphonuclear leukocytes. Methods Enzymol. 1988; 163:344-9.
  20. ↑ Soberman R. J. “Characterization and separation of the arachidonic acid 5-lipoxygenase and linoleic acid omega-6 lipoxygenase (arachidonic acid 15-lipoxygenase) of human polymorphonuclear leukocytes.” J Biol Chem. 1985 Apr 10;260(7):4508-15.
  21. ↑ Jacquot C. "Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases. Biochemistry. 2008 Jul 8;47(27):7295-303. doi: 10.1021/bi800308q. Epub 2008 Jun 12.
  22. ↑ Jacquot C. "Synthesis of 11-Thialinoleic Acid and 14-Thialinoleic Acid, Inhibitors of Soybean and Human Lipoxygenases Org Biomol Chem. 2008 Nov 21; 6(22): 4242–4252.
  23. ↑ Burrall B. "Enzymatic properties of the 15-lipoxygenase of human cultured keratinocytes. J Invest Dermatol. 1988 Oct;91(4):294-7.
  24. ↑ Sloane D. L. "Conversion of human 15-lipoxygenase to an efficient 12-lipoxygenase: the side-chain geometry of amino acids 417 and 418 determine positional specificity. Protein Eng. 1995 Mar;8(3):275-82..
  25. ↑ Liu L. "Functional mimicry of the active site of glutathione peroxidase by glutathione imprinted selenium-containing protein. Biomacromolecules. 2008 Jan;9(1):363-8. doi: 10.1021/bm7008312. Epub 2007 Dec 29.
  26. ↑ Zheng K. "A novel selenium-containing glutathione transferase zeta1-1, the activity of which surpasses the level of some native glutathione peroxidases. Int J Biochem Cell Biol. 2008;40(10):2090-7. doi: 10.1016/j.biocel.2008.02.006. Epub 2008 Feb 15.
  27. ↑ 27.0 27.1 Hiratsuka A. "Subunit Ya-specific glutathione peroxidase activity toward cholesterol 7-hydroperoxides of glutathione S-transferases in cytosols from rat liver and skin. J Biol Chem. 1997 Feb 21;272(8):4763-9.
  28. ↑ Lagarde M. "Subcellular localization and some properties of lipoxygenase activity in human blood platelets. Biochem J. 1984 Sep 1;222(2):495-500.
  29. ↑ Hada T. "Catalytic properties of human platelet 12-lipoxygenase as compared with the enzymes of other origins. Biochim Biophys Acta. 1991 Apr 24;1083(1):89-93.
  30. ↑ Chen X. S. "Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system. Eur J Biochem. 1993 Jun 15;214(3):845-52.
  31. ↑ Romano M. "Lipoxin synthase activity of human platelet 12-lipoxygenase. Biochem J. 1993 Nov 15;296 ( Pt 1):127-33.
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