Literature Parameters

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Enzyme Parameters

Reaction Enzyme E.C. Parameter Value Unit Species Reference
Transformation of FA to AA cPLA2a 3.1.1.4 Failed to parse (Cannot store math image on filesystem.): Km 0.05 mM Human Recombinant PLA2 (Phosphatidylcholine as the substrate) [1]
Failed to parse (Cannot store math image on filesystem.): Vmax 3 Failed to parse (Cannot store math image on filesystem.): μmol/min/mg
Failed to parse (Cannot store math image on filesystem.): Km 0.02 mM Human Recombinant PLA2 (Phosphatidylethanolamine as the substrate) [1]
Failed to parse (Cannot store math image on filesystem.): Vmax 70 Failed to parse (Cannot store math image on filesystem.): μmol/min/mg
Failed to parse (Cannot store math image on filesystem.): Km 0.413 ± 0.028 mM Rat PMN Neutrophils [2]
Transformation of AA to PGH2 COX-2 1.14.99.1 Failed to parse (Cannot store math image on filesystem.): Km 33 Failed to parse (Cannot store math image on filesystem.): μM Human PMN [3]
Failed to parse (Cannot store math image on filesystem.): Kcat 1000 min^{-1}
Failed to parse (Cannot store math image on filesystem.): Vmax 81.3 Failed to parse (Cannot store math image on filesystem.): nmol/min/mg Human [4]
Failed to parse (Cannot store math image on filesystem.): Km 16.2 Failed to parse (Cannot store math image on filesystem.): μM
Transformation of PGH2 to PGF2α PGFS 1.1.1.188 Failed to parse (Cannot store math image on filesystem.): Km 1.9 ± 1.5 Failed to parse (Cannot store math image on filesystem.): μM Human Placental Aldose Reductase (AKR1B1) [5]
Failed to parse (Cannot store math image on filesystem.): Vmax 26.0 ± 6.2 Failed to parse (Cannot store math image on filesystem.): nmol/min/mg
Failed to parse (Cannot store math image on filesystem.): Km 18 Failed to parse (Cannot store math image on filesystem.): μM Human Lung PGF2a Synthase (AKR1C3) [5]
Failed to parse (Cannot store math image on filesystem.): Vmax 4 Failed to parse (Cannot store math image on filesystem.): nmol/min/mg
Transformation of PGH2 to TXA2 TXAS 5.3.99.5 Failed to parse (Cannot store math image on filesystem.): Km 0.004 mM Platelet Free Human Monocyte [6]
Failed to parse (Cannot store math image on filesystem.): Km 10 Failed to parse (Cannot store math image on filesystem.): μM Human Thromboxane Synthase [7]
Failed to parse (Cannot store math image on filesystem.): Km 22 Failed to parse (Cannot store math image on filesystem.): μM Human Wild-Type TXAS [8]
Failed to parse (Cannot store math image on filesystem.): Vmax 0.00001599 Failed to parse (Cannot store math image on filesystem.): mmol/min/mg
Transformation of PGH2 to PGI2 PGIS 5.3.99.4 Failed to parse (Cannot store math image on filesystem.): Km 13.3 ± 1.4 Failed to parse (Cannot store math image on filesystem.): μM Human PGIS [9]
Failed to parse (Cannot store math image on filesystem.): Vmax 980 ± 42 Failed to parse (Cannot store math image on filesystem.): mole of PGI2 /min/mol of protein
Failed to parse (Cannot store math image on filesystem.): Km 9 ± 5 Failed to parse (Cannot store math image on filesystem.): μM Bovine Endothelial Cells [10]
Failed to parse (Cannot store math image on filesystem.): Vmax 2 ± 0.5 Failed to parse (Cannot store math image on filesystem.): µmol/min/mg
Transformation of PGH2 to PGD2 PGDS 5.3.99.2 Failed to parse (Cannot store math image on filesystem.): Km 0.004 mM Human Cerebrospinal Fluid [11]
Failed to parse (Cannot store math image on filesystem.): Km 0.0138 mM Human Wild Type Enzyme [12]
Failed to parse (Cannot store math image on filesystem.): Vmax 9.27 Failed to parse (Cannot store math image on filesystem.): μmol/min/mg
Transformation of PGH2 to PGE2 PGES 5.3.99.3 Failed to parse (Cannot store math image on filesystem.): Km 0.16 ± 0.004 mM Human Synovial Tissue [13]
Failed to parse (Cannot store math image on filesystem.): Km 0.215 mM Human Wild Type Enzyme [14]
Failed to parse (Cannot store math image on filesystem.): Vmax 170 ±20 Failed to parse (Cannot store math image on filesystem.): μmol/min/mg Human Recombinant His6-mPGES-1 [15]
Transformation of AA to 5-HPETE 5-LOX 1.13.11.34 Failed to parse (Cannot store math image on filesystem.): Km 0.0051 mM Human Recombinant 5-Lipoxygenase [16]
Failed to parse (Cannot store math image on filesystem.): Km 0.012 mM Human PMN Leukocyte [17]
Failed to parse (Cannot store math image on filesystem.): Km 63.1 Failed to parse (Cannot store math image on filesystem.): µM Human Polymorphonuclear Leukocytes [18]
Failed to parse (Cannot store math image on filesystem.): Vmax 5.3 Failed to parse (Cannot store math image on filesystem.): nmol/min/mg
Transformation of 5-HPETE to LTA4 5-LOX & FLAP 1.13.11.34 Failed to parse (Cannot store math image on filesystem.): Km X Failed to parse (Cannot store math image on filesystem.): μM Y A
Failed to parse (Cannot store math image on filesystem.): Kcat Z min^{-1}
Transformation of 5-HPETE to 5-HETE  ? D Failed to parse (Cannot store math image on filesystem.): Km X Failed to parse (Cannot store math image on filesystem.): μM Y A
Failed to parse (Cannot store math image on filesystem.): Kcat Z min^{-1}
Transformation of AA to 15-HPETE 15-LOX 1.13.11.33 Failed to parse (Cannot store math image on filesystem.): Km 3.7 ± 0.3 Failed to parse (Cannot store math image on filesystem.): μM Human Epithelium [19]
Failed to parse (Cannot store math image on filesystem.): Kcat 9.93 ± 0.28 Failed to parse (Cannot store math image on filesystem.): s^{-1}
Failed to parse (Cannot store math image on filesystem.): Km 0.005 mM Human Reticulocyte [20]
Failed to parse (Cannot store math image on filesystem.): Km 0.0106 mM Human Keratinocyte [21]
Failed to parse (Cannot store math image on filesystem.): Km 11.7 ± 0.9 Failed to parse (Cannot store math image on filesystem.): μM Human Wildtype 15-Lipoxygenase [22]
Failed to parse (Cannot store math image on filesystem.): Vmax 0.73 ± 0.20 Failed to parse (Cannot store math image on filesystem.): nmol/min/μg
Transformation of 15-HPETE to 15-HETE

Transformation of 12-HPETE to 12-HETE

PHGPx 1.11.1.9 Failed to parse (Cannot store math image on filesystem.): Km 0.3 mM Human Bioimprited Enzyme [23]
Failed to parse (Cannot store math image on filesystem.): Kcat 1170 ± 50 min^{-1}
Failed to parse (Cannot store math image on filesystem.): Km 11.1 ± 0.29 mM Human Wild Type Enzyme (Se-hGSTZ1-1) [24]
Failed to parse (Cannot store math image on filesystem.): Kcat 24500 ± 150 min^{-1}
Failed to parse (Cannot store math image on filesystem.): Vmax 511 Failed to parse (Cannot store math image on filesystem.): μmol/mg/min Rat liver cytosol Se-GSH Px (15-HPETE as the substrate) [25]
Failed to parse (Cannot store math image on filesystem.): Km 4 Failed to parse (Cannot store math image on filesystem.): μM Rat liver cytosol Se-GSH Px (5-HPETE as the substrate) [25]
Failed to parse (Cannot store math image on filesystem.): Vmax 65 Failed to parse (Cannot store math image on filesystem.): nmol/mg/min
Transformation of AA to 12-HPETE 12-LOX 1.13.11.31 Failed to parse (Cannot store math image on filesystem.): Km 0.0072 mM Human Platelet [26]
Failed to parse (Cannot store math image on filesystem.): Km 0.08 mM Human Platelet [27]
Failed to parse (Cannot store math image on filesystem.): Vmax 0.73 ± 0.20 Failed to parse (Cannot store math image on filesystem.): nmol/min/μg Human Wildtype 15-Lipoxygenase [22]
Failed to parse (Cannot store math image on filesystem.): Km 10 Failed to parse (Cannot store math image on filesystem.): µM Recombinant Histidine-Tagged Human Platelet 12-Lipoxygenase [28]
Failed to parse (Cannot store math image on filesystem.): Vmax 3 Failed to parse (Cannot store math image on filesystem.): µmol/min/mg

Non-Enzyme Catalysed Reaction Parameters

Reaction Parameter Value Unit Species Reference
Transformation of TXA2 to TXB2 Failed to parse (Cannot store math image on filesystem.): Kf X Failed to parse (Cannot store math image on filesystem.): μM Y A
Failed to parse (Cannot store math image on filesystem.): Kr Z min^{-1}
Transformation of PGI2 to 6-Keto-PGF2A Failed to parse (Cannot store math image on filesystem.): Kf X Failed to parse (Cannot store math image on filesystem.): μM Y A
Failed to parse (Cannot store math image on filesystem.): Kr Z min^{-1}
Transformation of PGD2 to PGJ2 Failed to parse (Cannot store math image on filesystem.): Kf X Failed to parse (Cannot store math image on filesystem.): μM Y A
Failed to parse (Cannot store math image on filesystem.): Kr Z min^{-1}
Transformation of PGJ2 to 15-Deoxy-PGJ2 Failed to parse (Cannot store math image on filesystem.): Kf X Failed to parse (Cannot store math image on filesystem.): μM Y A
Failed to parse (Cannot store math image on filesystem.): Kr Z min^{-1}
Transformation of 5-HETE to 5-Oxo-ETE Failed to parse (Cannot store math image on filesystem.): Kf X Failed to parse (Cannot store math image on filesystem.): μM Y A
Failed to parse (Cannot store math image on filesystem.): Kr Z min^{-1}
Transformation of LTA4 to LTB4 Failed to parse (Cannot store math image on filesystem.): Kf X Failed to parse (Cannot store math image on filesystem.): μM Y A
Failed to parse (Cannot store math image on filesystem.): Kr Z min^{-1}

References

  1. ↑ 1.0 1.1 Kawauchi Y. “Preparation and characterization of human rheumatoid arthritic synovial fluid phospholipase A2 produced by recombinant baculovirus-infected insect cells.” J Biochem. 1994 Jul;116(1):81-7.
  2. ↑ Kawauchi Y. “Changes in kinetic properties of cytosolic phospholipase A2 in activated rat neutrophils.” Adv Exp Med Biol. 1997;433:439-42.
  3. ↑ Yang K. “Finding multiple target optimal intervention in disease-related molecular network.” Mol Syst Biol 2008, (4):228
  4. ↑ S.F. Kim Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science 2005,310(5756):1966-70)
  5. ↑ 5.0 5.1 Z. Kabututu, M. Manin, Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1, 1B3 and 1B7. J Biochem 2009,145(2):161-8)
  6. ↑ M. Orlandi, G. Bartolini, Thromboxane A2 synthase activity in platelet free human monocytes. Biochim Biophys Acta. 1994 Dec 8;1215(3):285-90.
  7. ↑ R. Nusing, S. Schneider-Voss and V. Ullrich, Immunoaffinity purification of human thromboxane synthase. Arch Biochem Biophys. 1990 Aug 1;280(2):325-30.
  8. ↑ Hecker M. On the mechanism of prostacyclin and thromboxane A2 biosynthesis.J Biol Chem. 1989 Jan 5;264(1):141-50.
  9. ↑ H. C. Yeh, P. Y. Hsu, Characterization of heme environment and mechanism of peroxide bond cleavage in human prostacyclin synthase. Biochim Biophys Acta. 2005 Dec 30;1738(1-3):121-32.
  10. ↑ Hara S. , Isolation and molecular cloning of prostacyclin synthase from bovine endothelial cells. J Biol Chem. 1994 Aug 5;269(31):19897-903.
  11. ↑ Watanabe K. , "Structure-function analysis of human l-prostaglandin D synthase bound with fatty acid molecules. Biochem Biophys Res Commun. 1994 Sep 15;203(2):1110-6.
  12. ↑ Zhou Y. , "Identification of beta-trace as prostaglandin D synthase. FASEB J. 2010 Dec;24(12):4668-77. doi: 10.1096/fj.10-164863. Epub 2010 Jul 28.
  13. ↑ Pettersson P. , "Identification of beta-trace as prostaglandin D synthase. FASEB J. 2010 Dec;24(12):4668-77. doi: 10.1096/fj.10-164863. Epub 2010 Jul 28.
  14. ↑ Hamza A. , "Understanding microscopic binding of human microsomal prostaglandin E synthase-1 (mPGES-1) trimer with substrate PGH2 and cofactor GSH: insights from computational alanine scanning and site-directed mutagenesis. J Phys Chem B. 2010 Apr 29;114(16):5605-16. doi: 10.1021/jp100668y.
  15. ↑ Thoren S. , "Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination. J Biol Chem. 2003 Jun 20;278(25):22199-209. Epub 2003 Apr 2.
  16. ↑ Shirumalla R. K. “RBx 7,796: A novel inhibitor of 5-lipoxygenase.” Inflamm Res. 2006 Dec ; 55 (12) : 517-27.
  17. ↑ Soberman R. J. "5- and 15(omega-6)-lipoxygenases from human polymorphonuclear leukocytes. Methods Enzymol. 1988; 163:344-9.
  18. ↑ Soberman R. J. “Characterization and separation of the arachidonic acid 5-lipoxygenase and linoleic acid omega-6 lipoxygenase (arachidonic acid 15-lipoxygenase) of human polymorphonuclear leukocytes.” J Biol Chem. 1985 Apr 10;260(7):4508-15.
  19. ↑ Jacquot C. "Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases. Biochemistry. 2008 Jul 8;47(27):7295-303. doi: 10.1021/bi800308q. Epub 2008 Jun 12.
  20. ↑ Jacquot C. "Synthesis of 11-Thialinoleic Acid and 14-Thialinoleic Acid, Inhibitors of Soybean and Human Lipoxygenases Org Biomol Chem. 2008 Nov 21; 6(22): 4242–4252.
  21. ↑ Burrall B. "Enzymatic properties of the 15-lipoxygenase of human cultured keratinocytes. J Invest Dermatol. 1988 Oct;91(4):294-7.
  22. ↑ 22.0 22.1 Sloane D. L. "Conversion of human 15-lipoxygenase to an efficient 12-lipoxygenase: the side-chain geometry of amino acids 417 and 418 determine positional specificity. Protein Eng. 1995 Mar;8(3):275-82..
  23. ↑ Liu L. "Functional mimicry of the active site of glutathione peroxidase by glutathione imprinted selenium-containing protein. Biomacromolecules. 2008 Jan;9(1):363-8. doi: 10.1021/bm7008312. Epub 2007 Dec 29.
  24. ↑ Zheng K. "A novel selenium-containing glutathione transferase zeta1-1, the activity of which surpasses the level of some native glutathione peroxidases. Int J Biochem Cell Biol. 2008;40(10):2090-7. doi: 10.1016/j.biocel.2008.02.006. Epub 2008 Feb 15.
  25. ↑ 25.0 25.1 Hiratsuka A. "Subunit Ya-specific glutathione peroxidase activity toward cholesterol 7-hydroperoxides of glutathione S-transferases in cytosols from rat liver and skin. J Biol Chem. 1997 Feb 21;272(8):4763-9.
  26. ↑ Lagarde M. "Subcellular localization and some properties of lipoxygenase activity in human blood platelets. Biochem J. 1984 Sep 1;222(2):495-500.
  27. ↑ Hada T. "Catalytic properties of human platelet 12-lipoxygenase as compared with the enzymes of other origins. Biochim Biophys Acta. 1991 Apr 24;1083(1):89-93.
  28. ↑ Chen X. S. "Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system. Eur J Biochem. 1993 Jun 15;214(3):845-52.
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