Difference between revisions of "Degradation Pathways"

From ISMOC
Jump to: navigation, search
Line 8: Line 8:
 
{|width ="80%"
 
{|width ="80%"
 
|
 
|
* [[Decay of PGF2a/exPGF2a |Decay of PGF2a/exPGF2a ]]  
+
* [[Decay of AA to exAA|Decay of AA/exAA (R64/72) ]]
* [[Decay of TXB2/exTXB2 |Decay of TXB2/exTXB2]]  
+
* [[Decay of PGI2 to exPGI2 |Decay of PGI<sub>2</sub>/exPGI<sub>2</sub> (R48/77) ]]
* [[Decay of K6PGF2a to exK6PGF2a  |Decay of 6-keto-PGF1a/ex6-keto-PGF1a ]]  
+
* [[Decay of PGE2 to exPGE2 |Decay of PGE<sub>2</sub>/exPGE<sub>2</sub> (R49/76) ]]  
* [[Decay of PGE2 to exPGE2 |Decay of PGE2/exPGE2]]  
+
* [[Decay of PGF2a/exPGF2a |Decay of PGF<sub>2a</sub>/exPGF<sub>2a</sub> (R44/74) ]]  
* [[Decay of D15PGJ2 to exD15PGJ2 |Decay of 15-deoxy-PGJ2/ex15-deoxy-PGJ2 ]]  
+
* [[Decay of PGH2 to exPGH2 |Decay of PGH<sub>2</sub>/exPGH<sub>2</sub> (R53/73)  ]]  
* [[Decay of 5-Oxo-ETE to ex5-Oxo-ETE |Decay of 5-oxo-ETE/ex5-oxo-ETE]]  
+
* [[Decay of PGD2 to exPGD2 |Decay of PGD<sub>2</sub>/exPGD<sub>2</sub> (R52/78) ]]  
* [[Decay of 15-HETE to ex15-HETE |Decay of 15-HETE/ex15-HETE]]  
+
* [[Decay of PGJ2 to exPGJ2 |Decay of PGJ<sub>2</sub>/exPGJ<sub>2</sub> (R51/83) ]]  
* [[Decay of LTB4 to exLTB4 |Decay of LTB4/exLTB4]]  
+
* [[Decay of TXB2/exTXB2 |Decay of TXB<sub>2</sub>/exTXB<sub>2</sub> (R45/81) ]]  
* [[Decay of LTC4 to exLTC4 |Decay of LTC4/exLTC4]]
+
* [[Decay of TXA2 to exTXA2 |Decay of TXA<sub>2</sub>/exTXA<sub>2</sub> (R46/75) ]]  
* [[Decay of 12-HETE to ex12-HETE |Decay of 12-HETE/ex12-HETE]]  
+
* [[Decay of K6PGF2a to exK6PGF2a  |Decay of 6-keto-PGF<sub>1a</sub>/ex6-keto-PGF<sub>1a</sub> (R47/82)]]  
* [[Decay of TXA2 to exTXA2 |Decay of TXA2/exTXA2]]  
+
* [[Decay of D15PGJ2 to exD15PGJ2 |Decay of 15-deoxy-PGJ<sub>2</sub>/ex15-deoxy-PGJ<sub>2</sub> (R50/84) ]]  
* [[Decay of PGI2 to exPGI2 |Decay of PGI2/exPGI2]]  
+
* [[Decay of 15-Keto-PGE2 to ex15-Keto-PGE2  |Decay of 15-keto-PGE<sub>2</sub>/ex15-keto-PGE<sub>2</sub> (R68/79)]]  
* [[Decay of PGH2 to exPGH2 |Decay of PGH2/exPGH2 ]]  
+
* [[Decay of 3,4-Dihydro-15-Keto-PGE2  to ex3,4-Dihydro-15-Keto-PGE2  |Decay of 13,14-dihydro-15-keto-PGE<sub>2</sub>/ex13,14-dihydro-15-keto-PGE<sub>2</sub> (R71/80)]]  
* [[Decay of PGD2 to exPGD2 |Decay of PGD2/exPGD2]]  
+
* [[Decay of 5-Oxo-ETE to ex5-Oxo-ETE |Decay of 5-oxo-ETE/ex5-oxo-ETE  (R54/91) ]]  
* [[Decay of PGJ2 to exPGJ2 |Decay of PGJ2/exPGJ2]]  
+
* [[Decay of LTB4 to exLTB4 |Decay of LTB<sub>4</sub>/exLTB<sub>4</sub> (R56/93) ]]  
* [[Decay of 12-HPETE to ex12-HPETE |Decay of 12-HPETE/ex12-HPETE ]]  
+
* [[Decay of LTC4 to exLTC4 |Decay of LTC<sub>4</sub>/exLTC<sub>4</sub> (R57/94) ]]
* [[Decay of 15-HPETE to ex15-HPETE |Decay of 15-HPETE/ex15-HPETE ]]  
+
* [[Decay of LTA4 to exLTA4 |Decay of LTA<sub>4</sub>/exLTA<sub>4</sub> (R58/92) ]]  
* [[Decay of 5-HPETE to ex5-HPETE |Decay of 5-HPETE/ex5-HPETE ]]  
+
* [[Decay of 12-HPETE to ex12-HPETE |Decay of 12-HPETE/ex12-HPETE (R63/86) ]]  
* [[Decay of 5-HETE to ex5-HETE |Decay of 5-HETE/ex5-HETE ]]
+
* [[Decay of 15-HPETE to ex15-HPETE |Decay of 15-HPETE/ex15-HPETE (R61/85)]]  
* [[Decay of LTA4 to exLTA4 |Decay of LTA4/exLTA4 ]]
+
* [[Decay of 5-HPETE to ex5-HPETE |Decay of 5-HPETE/ex5-HPETE (R59/87) ]]  
* [[Decay of AA to exAA|Decay of AA/exAA ]]  
+
* [[Decay of 5-HETE to ex5-HETE |Decay of 5-HETE/ex5-HETE (R55/90) ]]  
* [[Decay of 15-Keto-PGE2 to ex15-Keto-PGE2  |Decay of 15-Keto-PGE2/ex15-Keto-PGE2 ]]  
+
* [[Decay of 15-HETE to ex15-HETE |Decay of 15-HETE/ex15-HETE (R60/88) ]]
* [[Decay of 3,4-Dihydro-15-Keto-PGE2  to ex3,4-Dihydro-15-Keto-PGE2  |Decay of 3,4-Dihydro-15-Keto-PGE2/ex3,4-Dihydro-15-Keto-PGE2 ]]  
+
* [[Decay of 12-HETE to ex12-HETE |Decay of 12-HETE/ex12-HETE (R62/89) ]]  
 
|}
 
|}
  

Revision as of 07:15, 17 May 2019

Return to overview

Upon being transported out of the cell, the eicosanoids accumulate in the interstitial fluid, which for simplicity is referred to as the extracellular compartment in the model. A decay constant was included for each extracellular metabolite to represent degradation. To describe the breaking down of metabolites an irreversible mass action rate law was used for reactions 43-64. The half life of each eicosanoid was initially assumed as 24 hours, but will be made metabolite specific when all of the values have been collected.

Pseudo-first order reactions.  k = ln(2)/t(0.5)

* Decay of LTB4/exLTB4 (R56/93)  


References