Difference between revisions of "Overview of Parameters"

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== Overview of Enzyme Parameters ==
 
== Overview of Enzyme Parameters ==
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A collection of literature parameters related to the model can be found [[Literature Parameters|'''here''']].
  
 
{|class="wikitable"
 
{|class="wikitable"
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|<math> min^{-1} </math>
 
|<math> min^{-1} </math>
 
|-
 
|-
−
|rowspan="4" | [[Transformation of AA to PGH2 |Transformation of AA to PGH2]]  
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|rowspan="2" | [[Transformation of AA to PGH2 |Transformation of AA to PGH2]]  
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|rowspan="4" | COX-2
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|rowspan="2" | COX-2
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|rowspan="4" | 1.14.99.1
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|rowspan="2" | 1.14.99.1
 
|<math>Km</math>  
 
|<math>Km</math>  
−
|33
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|X
 
|<math> μM </math>
 
|<math> μM </math>
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|rowspan="2" |Human PMN
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|rowspan="2" |Y
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|rowspan="2" |<ref name="Yang2008”>[Yang K. “Finding multiple target optimal intervention in disease-related molecular network.” Mol Syst Biol 2008, (4):228 http://www.ncbi.nlm.nih.gov/pubmed/18985027]</ref>
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|rowspan="2" |A
 
|-
 
|-
 
|<math>Kcat</math>  
 
|<math>Kcat</math>  
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|1000
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|Z
 
|<math> min^{-1} </math>
 
|<math> min^{-1} </math>
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|-
 
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|<math>Vmax</math>
 
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|81.3
 
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|<math> nmol/min/mg </math>
 
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|rowspan="2" |Human
 
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|rowspan="2" |<ref name="Kim2005"> [http://www.ncbi.nlm.nih.gov/pubmed/16373578 S.F. Kim Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2.'' Science 2005,310(5756):1966-70)]</ref>
 
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|-
 
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|<math>Km</math>
 
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|16.2
 
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|<math> μM </math>
 
 
|-
 
|-
 
|rowspan="2" | [[Transformation of PGH2 to PGF2α |Transformation of PGH2 to PGF2α]]
 
|rowspan="2" | [[Transformation of PGH2 to PGF2α |Transformation of PGH2 to PGF2α]]
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|rowspan="2" | 1.1.1.188
 
|rowspan="2" | 1.1.1.188
 
|<math>Km</math>  
 
|<math>Km</math>  
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|0.0019
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|X
−
|<math> mM </math>
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|<math> μM </math>
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|rowspan="2" |Human Placenta
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|rowspan="2" |Y
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|rowspan="2" |<ref name="Kabututu2009"> [http://www.ncbi.nlm.nih.gov/pubmed/19010934 Z. Kabututu, M. Manin, Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1, 1B3 and 1B7.'' J Biochem 2009,145(2):161-8)]</ref>
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|rowspan="2" |A
 
|-
 
|-
 
|<math>Kcat</math>  
 
|<math>Kcat</math>  
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|<math>Km</math>  
 
|<math>Km</math>  
 
|X
 
|X
−
|<math> nM </math>
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|<math> μM </math>
 
|rowspan="2" |Y
 
|rowspan="2" |Y
 
|rowspan="2" |A  
 
|rowspan="2" |A  
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|<math>Km</math>  
 
|<math>Km</math>  
 
|X
 
|X
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|<math> nM </math>
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|<math> μM </math>
 
|rowspan="2" |Y
 
|rowspan="2" |Y
 
|rowspan="2" |A  
 
|rowspan="2" |A  

Latest revision as of 17:50, 4 February 2016


Overview of Reaction Parameters

Reaction Enzyme E.C. Parameter Value Unit Species
Transformation of FA to AA PLA2 3.1.1.4 K X Failed to parse (Cannot store math image on filesystem.): μM Y
Transformation of AA to PGH2 COX-2 1.14.99.1 K X Failed to parse (Cannot store math image on filesystem.): μM Y
Transformation of PGH2 to PGF2α PGFS 1.1.1.188 K X nM Y
Transformation of PGH2 to TXA2 TXAS 5.3.99.5 K X nM Y
Transformation of PGH2 to PGI2 PGIS 5.3.99.4 K X nM Y
Transformation of PGH2 to PGD2 PGDS 5.3.99.2 K X nM Y
Transformation of PGH2 to PGE2 PGES 5.3.99.3 K X nM Y
Transformation of TXA2 to TXB2 K X nM Y
Transformation of PGI2 to 6-K-PGF1α K X nM Y
Transformation of PGD2 to PGJ2 K X nM Y
Transformation of PGJ2 to 15-D-PGJ2 K X nM Y

Overview of Enzyme Parameters

A collection of literature parameters related to the model can be found here.

Reaction Enzyme E.C. Parameter Value Unit Species Reference
Transformation of FA to AA PLA2 3.1.1.4 Failed to parse (Cannot store math image on filesystem.): Km X Failed to parse (Cannot store math image on filesystem.): μM Y A
Failed to parse (Cannot store math image on filesystem.): Kcat Z min^{-1}
Transformation of AA to PGH2 COX-2 1.14.99.1 Failed to parse (Cannot store math image on filesystem.): Km X Failed to parse (Cannot store math image on filesystem.): μM Y A
Failed to parse (Cannot store math image on filesystem.): Kcat Z min^{-1}
Transformation of PGH2 to PGF2α PGFS 1.1.1.188 Failed to parse (Cannot store math image on filesystem.): Km X Failed to parse (Cannot store math image on filesystem.): μM Y A
Failed to parse (Cannot store math image on filesystem.): Kcat Z min^{-1}
Transformation of PGH2 to TXA2 TXAS 5.3.99.5 Failed to parse (Cannot store math image on filesystem.): Km X Failed to parse (Cannot store math image on filesystem.): μM Y A
Failed to parse (Cannot store math image on filesystem.): Kcat Z min^{-1}
Transformation of PGH2 to PGI2 PGIS 5.3.99.4 Failed to parse (Cannot store math image on filesystem.): Km X Failed to parse (Cannot store math image on filesystem.): μM Y A
Failed to parse (Cannot store math image on filesystem.): Kcat Z min^{-1}
Transformation of PGH2 to PGD2 PGDS 5.3.99.2 Failed to parse (Cannot store math image on filesystem.): Km X nM Y A
Failed to parse (Cannot store math image on filesystem.): Kcat Z min^{-1}
Transformation of PGH2 to PGE2 PGES 5.3.99.3 Failed to parse (Cannot store math image on filesystem.): Km X nM Y A
Failed to parse (Cannot store math image on filesystem.): Kcat Z min^{-1}

Overview of Feedback Parameters

Feedback Parameter Value Unit Species
Failed to parse (Cannot store math image on filesystem.): Ki X Failed to parse (Cannot store math image on filesystem.): μM Y

Overview of Product Inhibition Parameters

Species Parameter Value Unit Species
Failed to parse (Cannot store math image on filesystem.): Ki X Failed to parse (Cannot store math image on filesystem.): μM Y

Overview of Decay Parameters

Species Parameter Value Unit Species
Failed to parse (Cannot store math image on filesystem.): Kd X Failed to parse (Cannot store math image on filesystem.): μM Y

Models

Insert models for keratinocytes and fibroblasts here

References

Retrieved from ‘http://www.systemsbiology.ls.manchester.ac.uk/wiki/index.php?title=Overview_of_Parameters&oldid=3724’