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In aqueous solutions containing serum albumin, PGJ2 is subject to an additional non-enzymatic dehydration reaction at the hydroxyl group of C15 to yield 15-deoxy-PGJ2. The products of these dehydration reactions have higher activity than the parent compound PGD2 [1].
Reaction
Chemical equation
Rate equation
Parameters
Note that the literature values are the same as reaction 8.
Association Rate Constant (Kf)
Literature values
| Value
|
Units
|
Conditions
|
Substrate
|
Weight
|
Reference
|
| 3.3E+6 (excluded)
|
M-1 min-1
|
25°C and 0.055 ionic strength
|
H2CO3 to CO2
|
32
|
[2]
|
| 4.5
|
M-1 min-1
|
20°C
|
HC(OH)2COOH
|
32
|
[3]
|
| 0.42
|
M-1 min-1
|
20°C
|
HC(OH)2COO–
|
32
|
[3]
|
Description of the reaction 9 Kf distribution
| Mode (M-1 s-1) |
Confidence Interval |
Location parameter (µ) |
Scale parameter (σ)
|
| 4.48E+00 |
1.09E+03 |
7.34E+00 |
2.42E+00
|
The estimated probability distribution for reaction 9 Kf. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.
Dissociation Rate Constant (Kr)
This is a “Dependent parameter”, meaning that the log-normal distribution for this parameter was calculated using multivariate distributions (this is discussed in detail here). As a result, no confidence interval factor or literature values were cited for this parameter.
Description of the reaction 9 Kr distribution
| Mode (M-1 s-1) |
Location parameter (µ) |
Scale parameter (σ)
|
| 9.25E-04 |
-6.07E+00 |
9.57E-01
|
The estimated probability distribution for reaction 9 Kr. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.
Dissociation Constant
Literature values
| Value
|
Units
|
Conditions
|
Substrate
|
Weight
|
Reference
|
| < 8E-04
|
N/A
|
OH Radicals in the Presence of Added Gas Phase HNO3 (3 ppmv n-pentadecane, 0.25, 0.50, 1.0, or 2.0 ppmv HNO3, 10 ppmv O3, and 2 ppmv TME were added from a glass bulb in a flow of N2)
|
Acid-Catalyzed Dehydration of Cyclic Hemiacetals (n-Pentadecane) in SOA
|
8
|
[4]
|
| 4E-04
|
N/A
|
PH of 100 cc. 0-02N NaHCO3, saturated with C02, into which 0 95 cc.
|
H2CO3
|
8
|
[5]
|
| 4.4E-4
|
N/A
|
In a 0O008 mol. solution of carbonic acid at 4°, 1-23 % is present as H2CO3
|
H2CO3
|
8
|
[6]
|
Description of the reaction 9 KD distribution
| Mode (M-1 s-1) |
Confidence Interval |
Location parameter (µ) |
Scale parameter (σ)
|
| 4.49E-04 |
1.38E+00 |
-7.61E+00 |
3.07E-01
|
The estimated probability distribution for reaction 9 KD. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.
Related Reactions
- Transformation of PGD2 to PGJ2
- ↑ Straus, D. S. Glass, C. K., Cyclopentenone prostaglandins: new insights on biological activities and cellular targets, Med Res Rev (2001), 21, 185-210.
- ↑ B. Gibbons "Rate of Hydration of Carbon Dioxide and Dehydration of Carbonic Acid at 25" J Biol Chem. 1963 Oct;238:3502-7
- ↑ 3.0 3.1 [hrcak.srce.hr/file/195437 Y.I. Tur'yan, "Kinetics and Equilibrium of the Dehydration-Hydration and Recombination-Dissociation Reactions of Glyoxylic Acid Investigated by Electrochemical Methods", CCACAA 71 (3) 727¿743 (1998)]
- ↑ A. Ranney "Kinetics of Acid-Catalyzed Dehydration of Cyclic Hemiacetals in Organic Aerosol Particles in Equilibrium with Nitric Acid Vapor" J. Phys. Chem. A, 2016, 120 (16), pp 2561–2568
- ↑ F. BUYTENDYK "A Study of the System Carbonic Acid, Carbon Dioxide and Water - Determination of the True Dissociation-constant of Carbonic Acid" Biochem J. 1927; 21(3): 576–584.
- ↑ Thiel and Strohecker (1914). Ber. deutsch. chem. Gem. 47, 945, 1061.
