Difference between revisions of "ATP-Binding Cassette Transporters"
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| − | * [[Transformation of PGF2a to exPGF2a |Transformation of PGF<sub>2a</sub> to exPGF<sub>2a</sub> ]] | + | * [[Transformation of PGF2a to exPGF2a |Transformation of PGF<sub>2a</sub> to exPGF<sub>2a</sub> (R22)]] |
| − | * [[Transformation of TXB2 to exTXB2 |Transformation of TXB<sub>2</sub> to exTXB<sub>2</sub>]] | + | * [[Transformation of TXB2 to exTXB2 |Transformation of TXB<sub>2</sub> to exTXB<sub>2</sub> (R23)]] |
| − | * [[Transformation of K6PGF2a to exK6PGF2a |Transformation of 6-keto-PGF<sub>1a</sub> to ex6-keto-PGF<sub>1a</sub> ]] | + | * [[Transformation of K6PGF2a to exK6PGF2a |Transformation of 6-keto-PGF<sub>1a</sub> to ex6-keto-PGF<sub>1a</sub> (R24)]] |
| − | * [[Transformation of PGE2 to exPGE2 |Transformation of PGE<sub>2</sub> to exPGE<sub>2</sub>]] | + | * [[Transformation of PGE2 to exPGE2 |Transformation of PGE<sub>2</sub> to exPGE<sub>2</sub> (R25)]] |
| − | * [[Transformation of D15PGJ2 to exD15PGJ2 |Transformation of 15-deoxy-PGJ<sub>2</sub> to ex15-deoxy-PGJ<sub>2</sub> ]] | + | * [[Transformation of D15PGJ2 to exD15PGJ2 |Transformation of 15-deoxy-PGJ<sub>2</sub> to ex15-deoxy-PGJ<sub>2</sub> (R26) ]] |
| − | * [[Transformation of 5-Oxo-ETE to ex5-Oxo-ETE |Transformation of 5-Oxo-ETE to ex5-Oxo-ETE]] | + | * [[Transformation of 5-Oxo-ETE to ex5-Oxo-ETE |Transformation of 5-Oxo-ETE to ex5-Oxo-ETE (R27)]] |
| − | * [[Transformation of 15-HETE to ex15-HETE |Transformation of 15-HETE to ex15-HETE]] | + | * [[Transformation of 15-HETE to ex15-HETE |Transformation of 15-HETE to ex15-HETE (R28)]] |
| − | * [[Transformation of LTB4 to exLTB4 |Transformation of LTB<sub>4</sub> to exLTB<sub>4</sub>]] | + | * [[Transformation of LTB4 to exLTB4 |Transformation of LTB<sub>4</sub> to exLTB<sub>4</sub> (R29)]] |
| − | * [[Transformation of LTC4 to exLTC4 |Transformation of LTC<sub>4</sub> to exLTC<sub>4</sub>]] | + | * [[Transformation of LTC4 to exLTC4 |Transformation of LTC<sub>4</sub> to exLTC<sub>4</sub> (R30)]] |
| − | * [[Transformation of 12-HETE to ex12-HETE |Transformation of 12-HETE to ex12-HETE]] | + | * [[Transformation of 12-HETE to ex12-HETE |Transformation of 12-HETE to ex12-HETE (R31)]] |
| − | * [[Transformation of TXA2 to exTXA2 |Transformation of TXA<sub>2</sub> to exTXA<sub>2</sub>]] | + | * [[Transformation of TXA2 to exTXA2 |Transformation of TXA<sub>2</sub> to exTXA<sub>2</sub> (R32)]] |
| − | * [[Transformation of PGI2 to exPGI2 |Transformation of PGI<sub>2</sub> to exPGI<sub>2</sub>]] | + | * [[Transformation of PGI2 to exPGI2 |Transformation of PGI<sub>2</sub> to exPGI<sub>2</sub> (R33)]] |
| − | * [[Transformation of PGH2 to exPGH2 |Transformation of PGH<sub>2</sub> to exPGH<sub>2</sub> ]] | + | * [[Transformation of PGH2 to exPGH2 |Transformation of PGH<sub>2</sub> to exPGH<sub>2</sub> (R34) ]] |
| − | * [[Transformation of PGD2 to exPGD2 |Transformation of PGD<sub>2</sub> to exPGD<sub>2</sub>]] | + | * [[Transformation of PGD2 to exPGD2 |Transformation of PGD<sub>2</sub> to exPGD<sub>2</sub> (R35)]] |
| − | * [[Transformation of PGJ2 to exPGJ2 |Transformation of PGJ<sub>2</sub> to exPGJ<sub>2</sub>]] | + | * [[Transformation of PGJ2 to exPGJ2 |Transformation of PGJ<sub>2</sub> to exPGJ<sub>2</sub> (R36)]] |
| − | * [[Transformation of 12-HPETE to ex12-HPETE |Transformation of 12-HPETE to ex12-HPETE ]] | + | * [[Transformation of 12-HPETE to ex12-HPETE |Transformation of 12-HPETE to ex12-HPETE (R37) ]] |
| − | * [[Transformation of 15-HPETE to ex15-HPETE |Transformation of 15-HPETE to ex15-HPETE ]] | + | * [[Transformation of 15-HPETE to ex15-HPETE |Transformation of 15-HPETE to ex15-HPETE (R38)]] |
| − | * [[Transformation of 5-HPETE to ex5-HPETE |Transformation of 5-HPETE to ex5-HPETE ]] | + | * [[Transformation of 5-HPETE to ex5-HPETE |Transformation of 5-HPETE to ex5-HPETE (R39)]] |
| − | * [[Transformation of 5-HETE to ex5-HETE |Transformation of 5-HETE to ex5-HETE ]] | + | * [[Transformation of 5-HETE to ex5-HETE |Transformation of 5-HETE to ex5-HETE (R40) ]] |
| − | * [[Transformation of LTA4 to exLTA4 |Transformation of LTA<sub>4</sub> to exLTA<sub>4</sub> ]] | + | * [[Transformation of LTA4 to exLTA4 |Transformation of LTA<sub>4</sub> to exLTA<sub>4</sub> (R41)]] |
| − | * [[Transformation of AA to exAA|Transformation of AA to exAA ]] | + | * [[Transformation of AA to exAA|Transformation of AA to exAA (R42)]] |
| − | * [[Transformation of 15-Keto-PGE2 to ex15-Keto-PGE2 |Transformation of 15-Keto-PGE<sub>2</sub> to ex15-Keto-PGE<sub>2</sub> ]] | + | * [[Transformation of 15-Keto-PGE2 to ex15-Keto-PGE2 |Transformation of 15-Keto-PGE<sub>2</sub> to ex15-Keto-PGE<sub>2</sub> (R43)]] |
| − | * [[Transformation of 3,4-Dihydro-15-Keto-PGE2 to ex3,4-Dihydro-15-Keto-PGE2 |Transformation of 3,4-Dihydro-15-Keto-PGE2 to ex3,4-Dihydro-15-Keto-PGE<sub>2</sub> ]] | + | * [[Transformation of 3,4-Dihydro-15-Keto-PGE2 to ex3,4-Dihydro-15-Keto-PGE2 |Transformation of 3,4-Dihydro-15-Keto-PGE2 to ex3,4-Dihydro-15-Keto-PGE<sub>2</sub> (R44) ]] |
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Revision as of 10:27, 16 May 2019
When a cell produces eicosanoids they are immediately transported into the extracellular compartment, as they are cytotoxic \cite{Pompeia2002}. An ATP-binding cassette (ABC) transporter has been assumed as the method of transportation across the cellular membrane for reactions 22-43.
An ABC transporter was assumed as the export transporter of lipids because it is widely reported as transporting organic molecules (ref). Due to the increased amount of free energy provided by the ATP hydrolysis reaction, the transporter is able to relocate molecules against a concentration gradient. The model only contains an inward facing transporter, although in reality there is also an outward facing variant.
In the literature a prostaglandin transporter is reported (Schuster2015), but due to the lack of kinetic analysis of the transporter, the ABC transporter was modelled. We assume that rate of transportation across the membrane may be similar between transporters, however once specific transporter kinetics become available, the model will be updated.
The rate law was designed to encompass the basic principles of an ATP transporter, e.g. the consumption of the internal lipid is directly proportional to amount of transporters. The ratio of substrate and product describes how the gradient would affect the rate of transportation, for example if the concentration of the external lipid equalled that of the internal, transportation would cease. The final term in the equation is the driving force for the transportation, calculated using Gibbs free energy of ATP hydrolysis, the gas constant, temperature and the concentrations of ATP and ADP. As the reformation of ATP is considerably faster than the lipid transporter the ratio was assumed to remain constant.
Contents
Reaction
Chemical equation
Rate equation
Parameters
References
