ATP-Binding Cassette Transporters

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At physiological pH, eicosanoids exist primarily as charged species and therefore exhibit poor membrane permeability [1]. Several studies have reported that eicosanoids are transported into the extracellular compartment via energy-dependant, active transport [2][3][4] [5][6].Responsible for this transport is an ATP-binding cassette (ABC) transporter, also known as a α-ketoglutarate organic anion exchanger and a prostaglandin specific organic anion transporter protein, OATP2A1 (PGT) [7]. Both transporters are a channel/pump located in the phospholipid bilayer of a cell, which binds and hydrolyses ATP to drive translocation of eicosanoids against a concentration gradient [8][9] [10].

The member of the ABC transporter family which is reported to transport eicosanoids is the multidrug resistance protein 4 (MRP4/ABCC4) [11][12]. The eicosanoid specificity of the ABC transporter has not been well explored beyond PGE2, but seems to be non-specific [13].


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ABC CI.PNG

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  • Svensson, C. I., Yaksh, T. L., The spinal phospholipase-cyclooxygenase-prostanoid cascade in nociceptive processing, Annu Rev Pharmacol Toxicol (2002), 42, 553-83.
  • Kochel, T. J. Fulton, A. M., Multiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancer, Prostaglandins Other Lipid Mediat (2015), 116-117, 99-103.
  • Lin, Z. P. Zhu, Y. L. Johnson, D. R. Rice, K. P. Nottoli, T. Hains, B. C. McGrath, J. Waxman, S. G. Sartorelli, A. C. , Disruption of cAMP and prostaglandin E2 transport by multidrug resistance protein 4 deficiency alters cAMP-mediated signaling and nociceptive response, Mol Pharmacol (2008), 73, 243-51.
  • Chan, B. S. Satriano, J. A. Pucci, M. Schuster, V. L. , Mechanism of prostaglandin E2 transport across the plasma membrane of HeLa Cells and Xenopus Oocytes expressing the prostaglandin transporter “PGT”, J Biol Chem (1998), 273, 6689-6697.
  • Schuster, V. L., Molecular mechanisms of prostaglandin transport, Prostaglandins Other Lipid Mediat (2002), 68-69, 633-47.
  • Baroody, R. A. Bito, L. Z. , The impermeability of the basic cell membrane to thromboxane-B2' prostacyclin and 6-keto-PGF 1 alpha, Prostaglandins (1981), 21, 133-42.
  • Schuster, V. L., Molecular mechanisms of prostaglandin transport, Prostaglandins Other Lipid Mediat (2002), 68-69, 633-47.
  • Higgins, C. F., ABC transporters: from microorganisms to man, Annu Rev Cell Biol (1992), 8, 67-113.
  • Dean, M. Allikmets, R., Evolution of ATP-binding cassette transporter genes, Curr Opin Genet Dev (1995), 5, 779-85.
  • Kanai, N. Lu, R. Satriano, J. A. Bao, Y. Wolkoff, A. W. Schuster, V. L. , Identification and characterization of a prostaglandin transporter , Science (1995), 268, 866-869.
  • Higgins, C. F., ABC transporters: from microorganisms to man, Annu Rev Cell Biol (1992), 8, 67-113.
  • Dean, M. Allikmets, R., Evolution of ATP-binding cassette transporter genes, Curr Opin Genet Dev (1995), 5, 779-85.
  • Schuster, V. L., Molecular mechanisms of prostaglandin transport, Prostaglandins Other Lipid Mediat (2002), 68-69, 633-47.
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