Kinetic model of Central Metabolism

A kinetic model of glycolysis with serine activation is constructed from the literature data .

Description of the model

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Reactions

Details of the abbreviations for this model is listed here

Glucose Transporter Hexokinase Pentose Phosphate Pathway Phosphoglucomutase UDPG-pyrophosphorylase Glycogen synthase Glycogen phosphorylase Hexose-6-phosphate isomerase Transketolase Phosphofructokinase type 1 Fructose 1,6 bisphosphate aldolase Adenylate kinase Dehydrogenase Triosephosphate isomerase Glyceraldehyde-3-phosphate dehydrogenase

3-phosphoglycerate kinase Phosphoglycerate dehydrogenase Phosphoserine amino-transferase Phosphohydroxypyruvate 3-phosphoglycerate mutase Enolase Pyruvate kinase ATPase Lactate dehydrogenase Monocarboxylate (Lactate) transporter Mitocondrial pyruvate metabolism Glycine hydroxymethyltransferase Serineout Glycineeout

Initial concentration of the metabolites can be found here

Global parameters

The Vmax value in the paper "Modeling cancer glycolysis" is given in $U \times \text{(mg total cellular protein)}^{-1}$ unit . To homogenize the units it is then converted back to $\frac{mM}{min}$ by multiplying $U \times \text{(mg total cellular protein)}^{-1}$ with 65 as the HeLa cell was incubated in $65 \frac{\text{mg protein}}{\text{mL cell volume}}$.