Transformation of PGH2 to PGF2α

From ISMOC
Revision as of 16:12, 10 April 2016 by Muttley93 (talk | contribs) (→‎Parameters)
Jump to: navigation, search

Return to overview

Reaction

R3 PGH2 -PGF2A.jpg

Chemical equation

FA \rightleftharpoons AA

Rate equation

Parameters

Michaelis-Menten Constants
Value Units Species Notes Reference
1.90E-03 ± 1.5E-03 mM Human Placental Aldose Reductase (AKR1B1) [1]
1.80E-02 mM Human Lung PGF2a Synthase (AKR1C3) [1]
Enzyme Turnover Numbers
Value Units Species Notes Reference
14.9 per minute Mouse/Swine Prostamide/PGF Synthase Purified

from Swine Brain and of Murine Enzyme Expressed in E. coli

[2]

References

  1. ↑ 1.0 1.1 Z. Kabututu, M. Manin, Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1, 1B3 and 1B7. J Biochem 2009,145(2):161-8)
  2. ↑ Moriuchi H., Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily. J Biol Chem. 2008 Jan 11;283(2):792-801.)


Related Reactions

Retrieved from ‘http://www.systemsbiology.ls.manchester.ac.uk/wiki/index.php?title=Transformation_of_PGH2_to_PGF2α&oldid=4356’