Transformation of PGH2 to PGE2

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Reaction

R10 PGH2 - PGE2.jpg

Chemical equation

FA \rightleftharpoons AA

Rate equation

Parameters

Michaelis-Menten Constants
Value Units Species Notes Reference
1.6E-01 ± 4.00E-03 mM Human Synovial Tissue [1]
2.15E-01 mM Human Wild Type Enzyme [2]
1.49E-02 mM Human cPGES, casein kinase II and Hsp90 [3]
6.66E-02 mM Human cPGES [3]
Enzyme Turnover Numbers
Value Units Species Notes Reference
X Y Z A B

References

  1. ↑ Pettersson P. , "Identification of beta-trace as prostaglandin D synthase. FASEB J. 2010 Dec;24(12):4668-77. doi: 10.1096/fj.10-164863. Epub 2010 Jul 28.
  2. ↑ Hamza A. , "Understanding microscopic binding of human microsomal prostaglandin E synthase-1 (mPGES-1) trimer with substrate PGH2 and cofactor GSH: insights from computational alanine scanning and site-directed mutagenesis. J Phys Chem B. 2010 Apr 29;114(16):5605-16. doi: 10.1021/jp100668y.
  3. ↑ 3.0 3.1 Kobayashi T. , "Regulation of cytosolic prostaglandin E synthase by phosphorylation. Biochem J. 2004 Jul 1;381(Pt 1):59-69.


Related Reactions

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