Difference between revisions of "Transformation of PGH2 to PGE2"

Revision as of 13:32, 8 April 2016

FA \rightleftharpoons AA

Michaelis-Menten Constants
Value	Units	Species	Notes	Reference
1.6E-01 ± 4.00E-03	$mM$	Human	Synovial Tissue	^[1]
2.15E-01	$mM$	Human	Wild Type Enzyme	^[2]
1.49E-02	$mM$	Human	cPGES, casein kinase II and Hsp90	^[3]
6.66E-02	$mM$	Human	cPGES	^[3]

Enzyme Turnover Numbers
Value	Units	Species	Notes	Reference
X	Y	Z	A	B

@@ Line 21: / Line 21: @@
 ! Reference
 |-
-| X
+|1.6E-01 ± 4.00E-03
-| Y
+|<math> mM </math>
-| Z
+|Human
-| A
+|Synovial Tissue
-| B
+|<ref name="Pettersson2005"> [http://www.ncbi.nlm.nih.gov/pubmed/16399384 Pettersson P. , "Identification of beta-trace as prostaglandin D synthase.'' FASEB J. 2010 Dec;24(12):4668-77. doi: 10.1096/fj.10-164863. Epub 2010 Jul 28.]</ref>
+|-
+|2.15E-01
+|<math> mM </math>
+|Human
+|Wild Type Enzyme
+|<ref name="Hamza2010"> [http://www.ncbi.nlm.nih.gov/pubmed/20369883 Hamza A. , "Understanding microscopic binding of human microsomal prostaglandin E synthase-1 (mPGES-1) trimer with substrate PGH2 and cofactor GSH: insights from computational alanine scanning and site-directed mutagenesis.'' J Phys Chem B. 2010 Apr 29;114(16):5605-16. doi: 10.1021/jp100668y.]</ref>
+|-
+|1.49E-02
+|<math> mM </math>
+|Human
+|cPGES, casein kinase II and Hsp90
+|<ref name="Kobayashi04"> [http://www.ncbi.nlm.nih.gov/pubmed/15040786 Kobayashi T. , "Regulation of cytosolic prostaglandin E synthase by phosphorylation.'' Biochem J. 2004 Jul 1;381(Pt 1):59-69.]</ref>
+|-
+|6.66E-02
+|<math> mM </math>
+|Human
+|cPGES
+|<ref name="Kobayashi04"></ref>
+|-
 |}
@@ Line 43: / Line 62: @@
 | B
 |}
+== References ==
+<references/>
 == Related Reactions ==
 * [[Transformation of AA to PGH2 |Transformation of AA to PGH2]]