Transformation of PGD2 to PGJ2

Return to overview

Due to the lack of PGD2 production by keratinocyte and fibroblast cells, the anti-inflammatory cyclopentanones, PGJ2 and 15d-PGJ2, will not be produced during early experimental procedures either.

Reaction

Chemical equation

$FA \rightleftharpoons AA$

Parameters

Association Rate Constant (Kf)

Value	Units	Conditions	Substrate	Reference
3.3E+6	M-1 min-1	25°C and 0.055 ionic strength	H2CO3 to CO2

Dissociation Rate Constant (Kr)

Value	Units	Conditions	Substrate	Reference

Dissociation Constant

Value	Units	Conditions	Substrate	Reference
< 8E-04	N/A	OH Radicals in the Presence of Added Gas Phase HNO3 (3 ppmv n-pentadecane, 0.25, 0.50, 1.0, or 2.0 ppmv HNO3, 10 ppmv O3, and 2 ppmv TME were added from a glass bulb in a flow of N2)	Acid-Catalyzed Dehydration of Cyclic Hemiacetals (n-Pentadecane) in SOA
4E-04	N/A	PH of 100 cc. 0-02N NaHCO3, saturated with C02, into which 0 95 cc.	H2CO3
4.4E-4	N/A	In a 0O008 mol. solution of carbonic acid at 4°, 1-23 % is present as H2CO3	H2CO3

Related Reactions

• Transformation of PGJ2 to 15-D-PGJ2

B. Gibbons "Rate of Hydration of Carbon Dioxide and Dehydration of Carbonic Acid at 25" J Biol Chem. 1963 Oct;238:3502-7

A. Ranney "Kinetics of Acid-Catalyzed Dehydration of Cyclic Hemiacetals in Organic Aerosol Particles in Equilibrium with Nitric Acid Vapor" J. Phys. Chem. A, 2016, 120 (16), pp 2561–2568

F. BUYTENDYK "A Study of the System Carbonic Acid, Carbon Dioxide and Water - Determination of the True Dissociation-constant of Carbonic Acid" Biochem J. 1927; 21(3): 576–584.

Thiel and Strohecker (1914). Ber. deutsch. chem. Gem. 47, 945, 1061.