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| == Related Reactions == | | == Related Reactions == |
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− | {| class="wikitable"
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− | ! style="text-align: center; font-weight: bold;" | Reaction #
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− | ! style="text-align: center; font-weight: bold;" | Species
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− | ! style="text-align: center; font-weight: bold;" | Half Life (min)
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− | ! style="text-align: center; font-weight: bold;" | Rate constant(min -1)
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− | ! style="text-align: center; font-weight: bold;" | Notes
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− | ! style="text-align: center; font-weight: bold;" | Reference
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− | |-
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− | | style="text-align: center;" | 44
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− | | style="text-align: center;" | exPGF2a
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− | | style="text-align: center;" | 528 ± 204
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− | | style="text-align: center;" | 0.001 ± 0.003
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− | | style="text-align: center;" |Study performed in decidual stromal cells and macrophages in culture.
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− | | style="text-align: center;" | <ref name="Ishihara1991”>[http://www.ncbi.nlm.nih.gov/pubmed/1789996 O. Ishihara, "Differences of metabolism of prostaglandin E2 and F2 alpha by decidual stromal cells and macrophages in culture." Eicosanoids. 1991;4(4):203-7.]</ref>
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− | |-
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− | | style="text-align: center;" | 45
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− | | style="text-align: center;" | exTXB2
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− | | style="text-align: center;" | 20 to 30
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− | | style="text-align: center;" | 0.035 to 0.023
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− | | style="text-align: center;" |Quoted in a textbook(https://books.google.co.uk/books?id=_9kEeTjyJdMC&pg=PA864&lpg=PA864&dq=half+life+txa2&source=bl&ots=2OTF4Mh2Jk&sig=hu79GprliUcW4QE_Zm79islesOA&hl=en&sa=X&ved=0ahUKEwj0oo2sgfjOAhXLIcAKHcaPDHQQ6AEIRjAI#v=onepage&q=half%20life%20txa2&f=false) with no ref.
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− | | style="text-align: center;" |
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− | |-
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− | | style="text-align: center;" | 46
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− | | style="text-align: center;" | exTXA2
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− | | style="text-align: center;" | 0.333
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− | | style="text-align: center;" | 2.079
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− | | style="text-align: center;" |Quoted in a textbook(https://books.google.co.uk/books?id=_9kEeTjyJdMC&pg=PA864&lpg=PA864&dq=half+life+txa2&source=bl&ots=2OTF4Mh2Jk&sig=hu79GprliUcW4QE_Zm79islesOA&hl=en&sa=X&ved=0ahUKEwj0oo2sgfjOAhXLIcAKHcaPDHQQ6AEIRjAI#v=onepage&q=half%20life%20txa2&f=false) with no ref.
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− | | style="text-align: center;" |
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− | |-
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− | | style="text-align: center;" | 47
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− | | style="text-align: center;" | ex6-KETO-PGF2A
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− | | style="text-align: center;" | 3
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− | | style="text-align: center;" | 0.231
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− | | style="text-align: center;" |Quoted in a textbook(https://books.google.co.uk/books?id=_9kEeTjyJdMC&pg=PA864&lpg=PA864&dq=half+life+txa2&source=bl&ots=2OTF4Mh2Jk&sig=hu79GprliUcW4QE_Zm79islesOA&hl=en&sa=X&ved=0ahUKEwj0oo2sgfjOAhXLIcAKHcaPDHQQ6AEIRjAI#v=onepage&q=half%20life%20txa2&f=false) with no ref.
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− | | style="text-align: center;" |
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− | |-
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− | | style="text-align: center;" | 48
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− | | style="text-align: center;" | exPGI2
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− | | style="text-align: center;" | 0.7
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− | | style="text-align: center;" | 0.990
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− | | style="text-align: center;" |
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− | | style="text-align: center;" |<ref name="Cawello1994”>[https://www.ncbi.nlm.nih.gov/pubmed/8070511 Cawello W., "Metabolism and pharmacokinetics of prostaglandin E1 administered by intravenous infusion in human subjects." Eur J Clin Pharmacol. 1994;46(3):275-7.]</ref>
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− | |-
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− | | style="text-align: center;" | 49
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− | | style="text-align: center;" | exPGE2
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− | | style="text-align: center;" | 900,± 492
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− | | style="text-align: center;" | 0.001 ± 0.001
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− | | style="text-align: center;" | Study performed in decidual stromal cells and macrophages in culture.
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− | | style="text-align: center;" | <ref name="Ishihara1991”>[http://www.ncbi.nlm.nih.gov/pubmed/1789996 O. Ishihara, "Differences of metabolism of prostaglandin E2 and F2 alpha by decidual stromal cells and macrophages in culture." Eicosanoids. 1991;4(4):203-7.]</ref>
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− | |-
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− | | style="text-align: center;" | 50
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− | | style="text-align: center;" | ex15-DEOXY-PGJ2
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− | | style="text-align: center;" | 720
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− | | style="text-align: center;" | 0.001
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− | | style="text-align: center;" | Dehydration of PGD2 to ultimatley 15d-PGJ2 occurs with a half life of about 12 hours in the presense of albumin (protien found in blood).
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− | | style="text-align: center;" | <ref name="Fitzpatrick1983”>[http://www.ncbi.nlm.nih.gov/pubmed/6578214 F. Fitzpatrick, "Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro." J Biol Chem. 1983 Oct 10;258(19):11713-8.]</ref>
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− | |-
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− | | style="text-align: center;" | 51
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− | | style="text-align: center;" | exPGJ2
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− | | style="text-align: center;" |
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− | | style="text-align: center;" |
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− | | style="text-align: center;" |
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− | | style="text-align: center;" |
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− | |-
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− | | style="text-align: center;" | 52
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− | | style="text-align: center;" | exPGD2
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− | | style="text-align: center;" | 1.5 - 1.6
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− | | style="text-align: center;" | 0.462 to 0.433
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− | | style="text-align: center;" | Human brain
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− | | style="text-align: center;" | <ref name="Suzuki1986”>[http://www.ncbi.nlm.nih.gov/pubmed/3465420 Suzuki F., "Transport of prostaglandin D2 into brain." Brain Res. 1986 Oct 22;385(2):321-8.]</ref>
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− | |-
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− | | style="text-align: center;" | 53
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− | | style="text-align: center;" | exPGH2
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− | | style="text-align: center;" | 5
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− | | style="text-align: center;" | 0.139
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− | | style="text-align: center;" | Quoted on supplier page (http://www.enzolifesciences.com/BML-PH002/prostaglandin-h2/)
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− | | style="text-align: center;" |
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− | |-
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− | | style="text-align: center;" | 54
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− | | style="text-align: center;" | ex5-OXO-ETE
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− | | style="text-align: center;" | 11
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− | | style="text-align: center;" | 0.064
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− | | style="text-align: center;" | Study in R15L Cells
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− | | style="text-align: center;" | <ref name="Cong2009”>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730384/ Cong W., "15-oxo-Eicosatetraenoic Acid, a Metabolite of Macrophage 15-Hydroxyprostaglandin Dehydrogenase That Inhibits Endothelial Cell Proliferation" Mol Pharmacol. 2009 Sep; 76(3): 516–525.]</ref>
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− | |-
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− | | style="text-align: center;" | 55
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− | | style="text-align: center;" | ex5-HETE
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− | | style="text-align: center;" |
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− | | style="text-align: center;" |
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− | | style="text-align: center;" |
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− | | style="text-align: center;" |
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− | |-
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− | | style="text-align: center;" | 56
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− | | style="text-align: center;" | exLTB4
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− | | style="text-align: center;" | 0.47 ± 0.02 to 0.63 ± 0.04
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− | | style="text-align: center;" | 1.475 ± 34.657 to 1.100 ± 17.329
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− | | style="text-align: center;" | Rabbit, Immunoreactive LTB4
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− | | style="text-align: center;" | <ref name="Marleau1994”>[http://www.ncbi.nlm.nih.gov/pubmed/8075884 Marleau S., "Metabolic disposition of leukotriene B4 (LTB4) and oxidation-resistant analogues of LTB4 in conscious rabbits." Br J Pharmacol. 1994 Jun;112(2):654-8.]</ref>
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− | |-
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− | | style="text-align: center;" | 57
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− | | style="text-align: center;" | exLTC4
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− | | style="text-align: center;" |
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− | | style="text-align: center;" |
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− | | style="text-align: center;" |
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− | | style="text-align: center;" |
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− | |-
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− | | style="text-align: center;" | 58
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− | | style="text-align: center;" | exLTA4
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− | | style="text-align: center;" | 0.05
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− | | style="text-align: center;" | 13.863
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− | | style="text-align: center;" | 37 degrees C
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− | | style="text-align: center;" | <ref name="Zimmer2004”>[http://www.jlr.org/content/45/11/2138.long Zimmer J., "Fatty acid binding proteins stabilize leukotriene A4 competition with arachidonic acid but not other lipoxygenase products" November 2004 The Journal of Lipid Research, 45, 2138-2144.]</ref>
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− | |-
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− | | style="text-align: center;" | 59
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− | | style="text-align: center;" | ex5-HPETE
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− | | style="text-align: center;" |
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− | | style="text-align: center;" |
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− | | style="text-align: center;" |
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− | | style="text-align: center;" |
| |
− | |-
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− | | style="text-align: center;" | 60
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− | | style="text-align: center;" | ex15-HETE
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− | | style="text-align: center;" | 21
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− | | style="text-align: center;" | 0.0331
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− | | style="text-align: center;" | Study in R15L Cells
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− | | style="text-align: center;" | <ref name="Cong2009”>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730384/ Cong W., "15-oxo-Eicosatetraenoic Acid, a Metabolite of Macrophage 15-Hydroxyprostaglandin Dehydrogenase That Inhibits Endothelial Cell Proliferation" Mol Pharmacol. 2009 Sep; 76(3): 516–525.]</ref>
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− | |-
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− | | style="text-align: center;" | 61
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− | | style="text-align: center;" | ex15-HPETE
| |
− | | style="text-align: center;" |
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− | | style="text-align: center;" |
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− | | style="text-align: center;" |
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− | | style="text-align: center;" |
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− | |-
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− | | style="text-align: center;" | 62
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− | | style="text-align: center;" | ex12-HETE
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− | | style="text-align: center;" | 180
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− | | style="text-align: center;" | 0.004
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− | | style="text-align: center;" | "During the first 2 min., the half-life of 12-HETE was 0.9 s, which implies
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− | a fast clearance of the compound from the circulation. However, during
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− | the subsequent half-hour the estimated half-life was 3 min. and increased
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− | dramatically at the interval of time from 30 to 60 min. (t1/2 around 3 h)."
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− | | style="text-align: center;" |<ref name="Dadaian1998”>[http://www.ncbi.nlm.nih.gov/pubmed/9661215 Dadaian M., "12-hydroxyeicosatetraenoic acid is a long-lived substance in the rabbit circulation." Prostaglandins Other Lipid Mediat. 1998 Jan;55(1):3-25.]</ref>
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− | |-
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− | | style="text-align: center;" | 63
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− | | style="text-align: center;" | ex12-HPETE
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− | | style="text-align: center;" | 0.5
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− | | style="text-align: center;" | 1.386
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− | | style="text-align: center;" |
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− | | style="text-align: center;" | <ref name="Maclouf1982”>[http://www.pnas.org/content/79/19/6042.abstract J. Maclouf, "Stimulation of leukotriene biosynthesis in human blood leukocytes by platelet-derived 12-hydroperoxy-icosatetraenoic acid" (1982) Proc. Natl. Acad. Sci. U. S. A. 79, 6042-6046 ]</ref>
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− | |-
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− | | style="text-align: center;" | 64
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− | | style="text-align: center;" | exAA
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− | | style="text-align: center;" | 240 to 660
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− | | style="text-align: center;" | 0.003 to 0.001
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− | | style="text-align: center;" |
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− | | style="text-align: center;" |<ref name="Vinge1985”>[http://www.ncbi.nlm.nih.gov/pubmed/3921386 Vinge E., "Arachidonic acid-induced platelet aggregation and prostanoid formation in whole blood in relation to plasma concentration of indomethacin." Eur J Clin Pharmacol. 1985;28(2):163-9.]</ref>
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| ==References== | | ==References== |
| <references/> | | <references/> |