Difference between revisions of "Transformation of LTA4 to LTC4"

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==References==
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== Related Reactions ==
 
== Related Reactions ==

Revision as of 16:42, 11 April 2016

Return to overview

Reaction

Chemical equation

 AA \rightleftharpoons PGH2

Rate equation

Parameters

Michaelis-Menten Constants
Value Units Species Notes Reference
0.3 �± 0.06 mM Human Wild Type hLTC4S, 20 °C, pH 7.8, incubated for 15 seconds. [1]
3.00E-02 ± 1.00E-02 mM Human Wild type, pH 7.8 [2]
Enzyme Turnover Numbers
Value Units Species Notes Reference
702 per minute Human Wild Type hLTC4S, 20 °C, pH 7.8, incubated for 15 seconds. [1]
1560 ± 240 per minute Human Wild Type, pH 7.8 [2]


References

  1. 1.0 1.1 [http://www.ncbi.nlm.nih.gov/pubmed/19010934 Rinaldo A. " Arginine 104 Is a Key Catalytic Residue in Leukotriene C4 Synthase J Biochem 2010, 285, 40771-40776]
  2. 2.0 2.1 [http://www.ncbi.nlm.nih.gov/pubmed/19010934 Niegowski D. " Crystal structures of Leukotriene C4 synthase in complex with product analogs, implications for the enzyme mechanism J. Biol. Chem. 289, 5199-5207 (2014)]

Related Reactions