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The metabolism of 5-HETE to 5-Oxo-ETE is catalysed by the enzyme 5-Hydroxyeicosanoid dehydrogenase (5-HEDH). This enzyme acts reversibly and has been reported to be found in skin (need to check). The product binds with the OXE receptor (Hosoi2002) and is 30-100 more bioactive than 5-HETE. 5-Oxo-ETE is a chemoattractant for neutrophils and eosinophils.
Reaction
Chemical equation
Rate equation
Parameters
Michaelis-Menten Constants
| Value
|
Units
|
Species
|
Notes
|
Reference
|
| X
|
Y
|
Z
|
A
|
B
|
Michaelis-Menten Constants
| Value
|
Units
|
Species
|
Notes
|
Reference
|
| X
|
Y
|
Z
|
A
|
B
|
Enzyme Turnover Number
| Value
|
Units
|
Species
|
Notes
|
Reference
|
| X
|
Y
|
Z
|
A
|
B
|
5-HEDH Abundance
| Value
|
Units
|
Species
|
Notes
|
Reference
|
| X
|
Y
|
Z
|
A
|
B
|
Gibbs Free energy
| Value
|
Units
|
Species
|
Notes
|
Reference
|
| X
|
Y
|
Z
|
A
|
B
|
Related Reactions
