Transformation of 12-HPETE to 12-HETE

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12-HPETE is reduced by phospholipid hydroperoxide glutathione peroxidase (PHGPx) to the corresponding alcohol, 12-HETE (Suth01). 12-HETE is found in high concentrations in the skin and is renowned for acting as a chemoattractant during inflammation, with binding sites on both LCs and keratinocyte cells (Dowd, Kobza Black et al. 1985).

Reaction

Chemical equation

$AA \rightleftharpoons PGH2$

Parameters

• See PHGPx parameters here.

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