Formation of homo-dimer R2

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Two ScbR (R) proteins bind together to form an ScbR homo-dimer (R2).

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Chemical equation

2R \rightleftharpoons R_{2}

Rate equation

 r= \frac{k^{-}_{6}}{K_{d6}}\cdot [R]^{2} - k^{-}_{6}\cdot [R_{2}]

Parameters

The parameters of this reaction are the dissociation constant for binding of one ScbR to another (K_{d6}) and the dissociation rate for binding of one ScbR to another (k^{-}_{6}).

Name Value Units Origin Remarks
K_{d6} 35.3 [1]  nM Studies with Streptomyces DnaA Protein
k^{-}_{6}  min^{-1}

Parameters with uncertainty

References

  1. Majka J, Zakrzewska-Czerwiñska J, Messer W. Sequence recognition, cooperative interaction, and dimerization of the initiator protein DnaA of Streptomyces. J Biol Chem. 2001;276(9):6243-52.