Degradation of r-a

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[NOTE TO MARC: Can you check the parameter for this reaction? I assumed the mRNA complex half life to be 1 min, is it too slow?]

The mRNA complex of scbR-scbA degrades very soon after it's formation.

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Chemical equation

r-a\rightarrow \varnothing

Rate equation

 r= d_{mAR}\cdot[r-a]

Parameters

The parameter of this reaction is the degradation rate of the r-a complex Failed to parse (Cannot store math image on filesystem.): D_{mRA} .

Name Value Units Origin Remarks
Failed to parse (Cannot store math image on filesystem.): d_{mRA} Failed to parse (Cannot store math image on filesystem.): 0.69 [1] [2] min^{-1} Assuming very fast degradation of coupled mRNA

Parameters with uncertainty

References

  1. Kimelman D. Kirschner M.W. An Antisense mRNA Directs the Covalent Modification of the Transcript Encoding Fibroblast Growth Factor in Xenopus Oocytes. Cell, 1969;(59):667-696.
  2. Eguchi Y, Itoh T, Tomizawa J. Antisense Rna. Annual Review of Biochemistry 1991;60: 631–652.