Degradation of C

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The SCB protein (C) degrades.

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Chemical equation

C\rightarrow \varnothing

Rate equation

 r= d_{C}\cdot[C]

Parameters

The parameter of this reaction is the degradation rate of C (d_{C}).

Name Value Units Origin Remarks
d_{C} 0-0.001 [1] min^{-1} Degradation rate of acyl-homoserine lactone (AHL) The assumption that the degradation of SCB1 is slower than

AHL is made, as described in Takano(2006)[2]

Parameters with uncertainty

The most plausible parameter value for the d_{C} is decided to be  0.0002 min^{-1} and the confidence interval  2 . This means that the mode of the PDF is 0.0002 and the range where 95% of the values are found is between 0.0001 and 0.0004 min^{-1}.

The probability distribution for the parameter, adjusted accordingly in order to reflect the above values, is the following:

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The location and scale parameters of the distribution are:

Parameter μ σ
d_{C} -8.4046 0.3356

References

  1. S. Basu, Y. Gerchman, C. H. Collins, F. H. Arnold & R. Weiss. A synthetic multicellular system for programmed pattern formation. Nature 434, 1130-1134, 2005
  2. E. Takano. γ-butyrolactones: Streptomyces signalling molecules regulating antibiotic production and differentiation. Current Opinion in Microbiology, 9(3):287–294, 2006.