Difference between revisions of "Decay of PGJ2 to exPGJ2"

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! style="text-align: center; font-weight: bold;" | Rate constant(min -1)
 
! style="text-align: center; font-weight: bold;" | Rate constant(min -1)
 
! style="text-align: center; font-weight: bold;" | Notes
 
! style="text-align: center; font-weight: bold;" | Notes
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! style="text-align: center; font-weight: bold;" | Weights
 
! style="text-align: center; font-weight: bold;" | Reference
 
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| style="text-align: center;" | Assumed the same as ex15-DEOXY-PGJ2 -
 
| style="text-align: center;" | Assumed the same as ex15-DEOXY-PGJ2 -
 
  Dehydration of PGD2 to ultimatley 15d-PGJ2 occurs with a half life of about 12 hours in the presense of albumin (protien found in blood).
 
  Dehydration of PGD2 to ultimatley 15d-PGJ2 occurs with a half life of about 12 hours in the presense of albumin (protien found in blood).
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| style="text-align: center;" |8
 
| style="text-align: center;" | <ref name="Fitzpatrick1983”>[http://www.ncbi.nlm.nih.gov/pubmed/6578214 F. Fitzpatrick, "Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro." J Biol Chem. 1983 Oct 10;258(19):11713-8.]</ref>
 
| style="text-align: center;" | <ref name="Fitzpatrick1983”>[http://www.ncbi.nlm.nih.gov/pubmed/6578214 F. Fitzpatrick, "Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro." J Biol Chem. 1983 Oct 10;258(19):11713-8.]</ref>
 
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Latest revision as of 14:55, 22 May 2019

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Return to Degradation Pathways


Rate equation

R51.PNG

Decay Parameters

Literature values
Reaction # Species Half Life (min) Rate constant(min -1) Notes Weights Reference
51 exPGJ2 720 0.001 Assumed the same as ex15-DEOXY-PGJ2 - 
Dehydration of PGD2 to ultimatley 15d-PGJ2 occurs with a half life of about 12 hours in the presense of albumin (protien found in blood).
8 [1]
Description of the PGJ2 decay constant distribution
Mode (min-1) Confidence Interval Location parameter (µ) Scale parameter (σ)
9.95E-04 1.10E+00 -6.90E+00 9.49E-02
The estimated probability distribution for PGJ2 decay constant. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.
The estimated probability distribution for exPGJ2 decay constant. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.

References

  1. ↑ F. Fitzpatrick, "Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro." J Biol Chem. 1983 Oct 10;258(19):11713-8.
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