Difference between revisions of "Decay of 12-HETE to ex12-HETE"

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== Decay Parameters ==
 
== Decay Parameters ==
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{| class="wikitable"
 
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|+  style="text-align: left;" | Literature values
 
! style="text-align: center; font-weight: bold;" | Reaction #
 
! style="text-align: center; font-weight: bold;" | Reaction #
 
! style="text-align: center; font-weight: bold;" | Species
 
! style="text-align: center; font-weight: bold;" | Species
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{| class="wikitable"
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|+  style="text-align: left;" | Description of the 12-HETE decay constant distribution
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! Mode (min-1) !! Confidence Interval  !! Location parameter (µ) !! Scale parameter (σ)
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| 3.83E-03 || 1.10E+00 || -5.56E+00 || 9.49E-02
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|}
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[[Image:100b.jpg|none|thumb|500px|The estimated probability distribution for 12-HETE decay constant. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.  ]]
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[[Image:100.jpg|none|thumb|500px|The estimated probability distribution for ex12-HETE decay constant. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.  ]]
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== References ==
 
== References ==
 
<references/>
 
<references/>

Revision as of 13:37, 16 May 2019

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Return to Degradation Pathways


Rate equation

R62.PNG

Decay Parameters

Literature values
Reaction # Species Half Life (min) Rate constant(min -1) Notes Reference
62 ex12-HETE 180 0.004 "During the first 2 min., the half-life of 12-HETE was 0.9 s, which implies

a fast clearance of the compound from the circulation. However, during the subsequent half-hour the estimated half-life was 3 min. and increased dramatically at the interval of time from 30 to 60 min. (t1/2 around 3 h)."

[1]
Description of the 12-HETE decay constant distribution
Mode (min-1) Confidence Interval Location parameter (µ) Scale parameter (σ)
3.83E-03 1.10E+00 -5.56E+00 9.49E-02
The estimated probability distribution for 12-HETE decay constant. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.
The estimated probability distribution for ex12-HETE decay constant. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.

References

  1. ↑ Dadaian M., "12-hydroxyeicosatetraenoic acid is a long-lived substance in the rabbit circulation." Prostaglandins Other Lipid Mediat. 1998 Jan;55(1):3-25.
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