Antisense interaction between r and a
[NOTE TO MARC: Can you also check the parameter for this reaction? I found those papers cited below. Also, is the reaction reversible or irreversible? In Chatterjee they have modelled it as reversible. If it is, we are missing one parameter, because I only could find that one below.]
The full length mRNA of scbR (r) binds to the full length mRNA of scbA (a) and form a complex which prevents further translation of both mRNAs.
Contents
Chemical equation
Rate equation
Parameters
The parameter of this reaction is the dissociation constant for binding of scbR mRNA to scbA mRNA (Failed to parse (Cannot store math image on filesystem.): K_{ra} ).
Name | Value | Units | Origin | Remarks |
---|---|---|---|---|
Failed to parse (Cannot store math image on filesystem.): 0.06-0.18 [1] [2] [3] | Failed to parse (Cannot store math image on filesystem.): nM^{-1} \cdot min^{-1} | |||
Failed to parse (Cannot store math image on filesystem.): K_{-ar} |
Parameters with uncertainty
The most plausible parameter value for the is decided to be and the confidence interval . This means that the mode of the PDF is 5 and the range where 95% of the values are found is between ?? and ??.
The probability distributions for the two parameters, adjusted accordingly in order to reflect the above values, are the following:
The location and scale parameters of the distribution are:
Parameter | μ | σ |
---|---|---|
References
- ↑ Shokeen S, Johnson CM, Greenfield TJ, Manias DA, Dunny GM, Weaver KE. Structural analysis of the Anti-Q-Qs interaction: RNA-mediated regulation of E. faecalis plasmid pCF10 conjugation. Plasmid. 2010;64(1):26-35.
- ↑ Brantl S. Regulatory mechanisms employed by cis-encoded antisense RNAs. Cell regulation (RNA special issue). 2007; 10: 102–109.
- ↑ Eguchi Y, Itoh T, Tomizawa J (1991) Antisense Rna. Annual Review of Biochemistry 60: 631–652.