Difference between revisions of "ATP-Binding Cassette Transporters"

Revision as of 17:23, 19 May 2016

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Michaelis-Menten Constants
Value	Units	Species	Notes	Reference
0.0109 ± 0.00391	mM	Human	Substrate: LTC4 pH 7.0, 37°C, recombinant MRP2, using 4mM MgATP and 5g of isolated membranes.	^[1]
0.0000366 ± 0.0000038	mM	Human	Substrate LTC4, 37 °C, 4 mM ATP,	^[2]
5.3E-3 ± 2.6E-3	mM	Human	4 mM ATP, 37°C, 5–10 ml of membrane vesicle suspension (30 mg protein).	^[3]

Turnover Number
Value	Units	Species	Notes	Reference
11.34	per minute	Human	Substrate: ATP	^[1]

Vmax ***
Value	Units	Species	Notes	Reference
190.9 ± 19.6	nmol Pi/min/mg protein	Human	Substrate: LTC4 pH 7.0, 37°C, recombinant MRP2, using 4mM MgATP and 5g of isolated membranes.	^[1]
125 ± 12	pmol/min/mg	Human	Substrate LTC4, 37 °C, 4 mM ATP,	^[2]
20.2 ± 5.9	pmol/mg/min	Human	4 mM ATP, 37°C, 5–10 ml of membrane vesicle suspension (30 mg protein).	^[3]

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 {|class="wikitable sortable"
-|+  style="text-align: left;" | Protein Concentrations
+|+  style="text-align: left;" | Turnover Number
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 ! Value
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 ! Reference
 |-
+|11.34
+|per minute
+|Human
+|Substrate: ATP
+|<ref name="Yas2007"> [http://onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2009.07072.x/abstract;jsessionid=C62D36B7C02D54530D521224C3C52976.f01t03 Sato, T "Functional role of the linker region in purified human P-glycoprotein''   FEBS J. 276, 3504-3516 (2009))]</ref>
+|-
 |}