Transformation of PGD2 to PGJ2

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Due to the lack of PGD2 production by keratinocyte and fibroblast cells, the anti-inflammatory cyclopentanones, PGJ2 and 15d-PGJ2, will not be produced during early experimental procedures either.


Reaction

R8 PGD2 - PGJ2.jpg

Chemical equation

PGD2\rightleftharpoons PGJ2

Rate equation

R08.PNG

Parameters

Association Rate Constant (Kf)
Value Units Conditions Substrate Reference
3.3E+6 M-1 min-1 25°C and 0.055 ionic strength H2CO3 to CO2 [1]
4.5 M-1 min-1 20°C HC(OH)2COOH [2]
0.42 M-1 min-1 20°C HC(OH)2COO– [2]
Dissociation Rate Constant (Kr)
Value Units Conditions Substrate Reference
Dissociation Constant
Value Units Conditions Substrate Reference
< 8E-04 N/A OH Radicals in the Presence of Added Gas Phase HNO3 (3 ppmv n-pentadecane, 0.25, 0.50, 1.0, or 2.0 ppmv HNO3, 10 ppmv O3, and 2 ppmv TME were added from a glass bulb in a flow of N2) Acid-Catalyzed Dehydration of Cyclic Hemiacetals (n-Pentadecane) in SOA
Cyclic Hemiacetals.PNG
 [3]
4E-04 N/A PH of 100 cc. 0-02N NaHCO3, saturated with C02, into which 0 95 cc. H2CO3 [4]
4.4E-4 N/A In a 0O008 mol. solution of carbonic acid at 4°, 1-23 % is present as H2CO3 H2CO3 [5]

Related Reactions

References

  1. ↑ B. Gibbons "Rate of Hydration of Carbon Dioxide and Dehydration of Carbonic Acid at 25" J Biol Chem. 1963 Oct;238:3502-7
  2. ↑ 2.0 2.1 [hrcak.srce.hr/file/195437 Y.I. Tur'yan, "Kinetics and Equilibrium of the Dehydration-Hydration and Recombination-Dissociation Reactions of Glyoxylic Acid Investigated by Electrochemical Methods", CCACAA 71 (3) 727¿743 (1998)]
  3. ↑ A. Ranney "Kinetics of Acid-Catalyzed Dehydration of Cyclic Hemiacetals in Organic Aerosol Particles in Equilibrium with Nitric Acid Vapor" J. Phys. Chem. A, 2016, 120 (16), pp 2561–2568
  4. ↑ F. BUYTENDYK "A Study of the System Carbonic Acid, Carbon Dioxide and Water - Determination of the True Dissociation-constant of Carbonic Acid" Biochem J. 1927; 21(3): 576–584.
  5. ↑ Thiel and Strohecker (1914). Ber. deutsch. chem. Gem. 47, 945, 1061.
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