Transformation of PGH2 to PGE2

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Revision as of 14:30, 18 August 2016 by Muttley93 (talk | contribs) (PGES Enzyme Parameters)
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Reaction

R10 PGH2 - PGE2.jpg

Chemical equation

 FA \rightleftharpoons AA

Rate equation

PGES Enzyme Parameters

Michaelis-Menten Constants
Value Units Species Notes Reference
1.6E-01 ± 4.00E-03  mM Human Expression Vector: E. Coli

Enzyme: PGES pH: 8 Temperature: 37

[1]
2.15E-01  mM Human Wild Type Enzyme [2]
1.49E-02  mM Human Expression Vector: E. Coli

Enzyme: PGES pH: Unknown Temperature: Unknown

Other: cPGES, casein kinase II and Hsp90

[3]
6.66E-02  mM Human Expression Vector: E. Coli

Enzyme: PGES pH: Unknown Temperature: Unknown

[3]
Enzyme Turnover Numbers
Value Units Species Notes Reference
3000 ± 360 per minute Human Expression Vector: E. Coli.

Enzyme: Microsomal Prostaglandin E Synthase pH: 7.5 Temperature: 37

[4]
PGES Abundance
Value Units Species Notes Reference
220  ppm Human Expression Vector: Placenta

Enzyme: PGES pH: 7.5 Temperature: 37 °C

[5]
75.3  ppm Human Expression Vector: Urinary Bladder

Enzyme: PGES pH: 7.5 Temperature: 37 °C

[6]
208  ppm Human Expression Vector: Stomach

Enzyme: PGES pH: 7.5 Temperature: 37 °C

[5]
28.1  ppm Human Expression Vector: Lung

Enzyme: PGES pH: 7.5 Temperature: 37 °C

[6]
11.6  ppm Human Expression Vector: Colon

Enzyme: PGES pH: 7.5 Temperature: 37 °C

[6]
Gibbs Free Energy Change
Value Units Species Notes Reference
5.72 kcal/mol Not stated Estimated

Enzyme: PGES Substrate: Arachidonate Product: PGE2 pH: 7.3 ionic strength: 0.25

[7]

References


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