Phosphofructokinase type 1
The enzyme Phosphofructokinase Type-1 uses another ATP molecule to transfer a phosphate group to fructose 6-phosphate to form fructose 1, 6-bisphosphate. PFK-1 is an allosteric enzyme showing cooperative behaviour with Fru6P and hyperbolic kinetics with ATP.
Chemical equation
![Fru6P + ATP \rightleftharpoons Fru1,6BP + ADP](/wiki/images/math/f/9/3/f931feed721084327fc70fe25f43784b.png)
Rate equation
The concerted transition model of Monod, Wyman and Changeux (MWC model) is used as a rate equation for this tetrameric enzyme for considering exclusive ligand binding (F6P, activators and inhibitors).
![\left(\left(\frac{\frac{[ATP]}{K_{ATP}}}{1 + \frac{[ATP]}{K_{ATP}} }\right) \right)](/wiki/images/math/0/e/1/0e1525d4ee73ae42f7dbc443dceabcf0.png)