Transformation of PGD2 to PGJ2

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Due to the lack of PGD2 production by keratinocyte and fibroblast cells, the anti-inflammatory cyclopentanones, PGJ2 and 15d-PGJ2, will not be produced during early experimental procedures either.


Reaction

R8 PGD2 - PGJ2.jpg

Chemical equation

 PGD2\rightleftharpoons PGJ2

Rate equation

R08.PNG

Parameters

Association Rate Constant (Kf)

Literature values
Value Units Conditions Substrate Reference
3.3E+6 (excluded) M-1 min-1 25°C and 0.055 ionic strength H2CO3 to CO2 [1]
4.5 M-1 min-1 20°C HC(OH)2COOH [2]
0.42 M-1 min-1 20°C HC(OH)2COO– [2]
Description of the reaction 8 Kf distribution
Mode (M-1 s-1) Confidence Interval Location parameter (µ) Scale parameter (σ)
4.48E+00 1.09E+03 7.34E+00 2.42E+00
The estimated probability distribution for reaction 8 Kf. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.


Dissociation Rate Constant (Kr)

This is a “Dependent parameter”, meaning that the log-normal distribution for this parameter was calculated using multivariate distributions (this is discussed in detail here). As a result, no confidence interval factor or literature values were cited for this parameter.

Description of the reaction 8 Kr distribution
Mode (M-1 s-1) Location parameter (µ) Scale parameter (σ)
9.25E-04 -6.07E+00 9.57E-01
The estimated probability distribution for reaction 8 Kr. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.

Dissociation Constant

Literature values
Value Units Conditions Substrate Reference
< 8E-04 N/A OH Radicals in the Presence of Added Gas Phase HNO3 (3 ppmv n-pentadecane, 0.25, 0.50, 1.0, or 2.0 ppmv HNO3, 10 ppmv O3, and 2 ppmv TME were added from a glass bulb in a flow of N2) Acid-Catalyzed Dehydration of Cyclic Hemiacetals (n-Pentadecane) in SOA
Cyclic Hemiacetals.PNG
[3]
4E-04 N/A PH of 100 cc. 0-02N NaHCO3, saturated with C02, into which 0 95 cc. H2CO3 [4]
4.4E-4 N/A In a 0O008 mol. solution of carbonic acid at 4°, 1-23 % is present as H2CO3 H2CO3 [5]
Description of the reaction 8 KD distribution
Mode (M-1 s-1) Confidence Interval Location parameter (µ) Scale parameter (σ)
4.49E-04 1.38E+00 -7.61E+00 3.07E-01
The estimated probability distribution for reaction 8 KD. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.

Related Reactions

References