Transformation of PGH2 to PGE2

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Reaction

R10 PGH2 - PGE2.jpg

Chemical equation

 FA \rightleftharpoons AA

Rate equation

PGES Enzyme Parameters

Michaelis-Menten Constants
Value Units Species Notes Reference
1.6E-01 ± 4.00E-03  mM Human Synovial Tissue [1]
2.15E-01  mM Human Wild Type Enzyme [2]
1.49E-02  mM Human cPGES, casein kinase II and Hsp90 [3]
6.66E-02  mM Human cPGES [3]
Enzyme Turnover Numbers
Value Units Species Notes Reference
3000 ± 360 per minute Human Microsomal Prostaglandin E Synthase 1 expressed in E. Coli. [4]
Enzyme Concentrations
Value Units Species Notes Reference
0.00002353 mM Human 40ng/100ul of a 17 kDa protein

Synovial Tissue

[1]
0.47059 mM Human 8 mg/mL of 17kDa of protien [2]

References


Related Reactions