Difference between revisions of "Transformation of PGD2 to PGJ2"
(→Parameters) |
|||
Line 1: | Line 1: | ||
[[Welcome to the In-Silico Model of Cutaneous Lipids Wiki | Return to overview]] | [[Welcome to the In-Silico Model of Cutaneous Lipids Wiki | Return to overview]] | ||
− | + | PGD2 is subsequently converted to PGJ2 via a non-enzymatic dehydration reaction <ref>Fitzpatrick, F. A. Wynalda, M. A., ''Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro'', J Biol Chem (1983), 258, 11713-8.</ref>. This dehydration reaction takes place in an aqueous solution and includes the removal of two hydrogens and one oxygen molecule. This reaction occurs across the C9 hydroxyl and the C10 carbon axis, to form a double bond between C9 and 10. | |
Latest revision as of 08:09, 21 August 2019
PGD2 is subsequently converted to PGJ2 via a non-enzymatic dehydration reaction [1]. This dehydration reaction takes place in an aqueous solution and includes the removal of two hydrogens and one oxygen molecule. This reaction occurs across the C9 hydroxyl and the C10 carbon axis, to form a double bond between C9 and 10.
Contents
Reaction
Chemical equation
Rate equation
Parameters
Association Rate Constant (Kf)
Value | Units | Conditions | Substrate | Weight | Reference |
---|---|---|---|---|---|
3.3E+6 (excluded) | M-1 min-1 | 25°C and 0.055 ionic strength | H2CO3 to CO2 | 32 | [2] |
4.5 | M-1 min-1 | 20°C | HC(OH)2COOH | 32 | [3] |
0.42 | M-1 min-1 | 20°C | HC(OH)2COO– | 32 | [3] |
Mode (M-1 s-1) | Confidence Interval | Location parameter (µ) | Scale parameter (σ) |
---|---|---|---|
4.48E+00 | 1.09E+03 | 7.34E+00 | 2.42E+00 |
Dissociation Rate Constant (Kr)
This is a “Dependent parameter”, meaning that the log-normal distribution for this parameter was calculated using multivariate distributions (this is discussed in detail here). As a result, no confidence interval factor or literature values were cited for this parameter.
Mode (M-1 s-1) | Location parameter (µ) | Scale parameter (σ) |
---|---|---|
9.25E-04 | -6.07E+00 | 9.57E-01 |
Dissociation Constant
Value | Units | Conditions | Substrate | Weight | Reference |
---|---|---|---|---|---|
< 8E-04 | N/A | OH Radicals in the Presence of Added Gas Phase HNO3 (3 ppmv n-pentadecane, 0.25, 0.50, 1.0, or 2.0 ppmv HNO3, 10 ppmv O3, and 2 ppmv TME were added from a glass bulb in a flow of N2) | Acid-Catalyzed Dehydration of Cyclic Hemiacetals (n-Pentadecane) in SOA | 8 | [4] |
4E-04 | N/A | PH of 100 cc. 0-02N NaHCO3, saturated with C02, into which 0 95 cc. | H2CO3 | 8 | [5] |
4.4E-4 | N/A | In a 0O008 mol. solution of carbonic acid at 4°, 1-23 % is present as H2CO3 | H2CO3 | 8 | [6] |
Mode (M-1 s-1) | Confidence Interval | Location parameter (µ) | Scale parameter (σ) |
---|---|---|---|
4.49E-04 | 1.38E+00 | -7.61E+00 | 3.07E-01 |
Related Reactions
References
- ↑ Fitzpatrick, F. A. Wynalda, M. A., Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro, J Biol Chem (1983), 258, 11713-8.
- ↑ B. Gibbons "Rate of Hydration of Carbon Dioxide and Dehydration of Carbonic Acid at 25" J Biol Chem. 1963 Oct;238:3502-7
- ↑ 3.0 3.1 [hrcak.srce.hr/file/195437 Y.I. Tur'yan, "Kinetics and Equilibrium of the Dehydration-Hydration and Recombination-Dissociation Reactions of Glyoxylic Acid Investigated by Electrochemical Methods", CCACAA 71 (3) 727¿743 (1998)]
- ↑ A. Ranney "Kinetics of Acid-Catalyzed Dehydration of Cyclic Hemiacetals in Organic Aerosol Particles in Equilibrium with Nitric Acid Vapor" J. Phys. Chem. A, 2016, 120 (16), pp 2561–2568
- ↑ F. BUYTENDYK "A Study of the System Carbonic Acid, Carbon Dioxide and Water - Determination of the True Dissociation-constant of Carbonic Acid" Biochem J. 1927; 21(3): 576–584.
- ↑ Thiel and Strohecker (1914). Ber. deutsch. chem. Gem. 47, 945, 1061.