Difference between revisions of "Phosphofructokinase type 1"
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− | \left(\left(\frac{\frac{[ATP]}{K_{ATP}}}{1 + \frac{[ATP]}{K_{ATP}} }\right) \left( \frac{ 1 + \frac{\beta Fru2,6BP}{ \alpha Ka_{Fru2,6BP} } }{ 1 + \frac{Fru2,6BP}{ \alpha Ka_{Fru2,6BP} } } \right) \right) | + | \left(\left(\frac{\frac{[ATP]}{K_{ATP}}}{1 + \frac{[ATP]}{K_{ATP}} }\right) \left( \frac{ 1 + \frac{\beta Fru2,6BP}{ \alpha Ka_{Fru2,6BP} } }{ 1 + \frac{Fru2,6BP}{ \alpha Ka_{Fru2,6BP} } } \right) |
+ | |||
+ | \left ( \frac{\frac{Fru6P \left ( 1 + \frac{Fru2,6BP}{\alpha Ka_{Fru2,6BP}} \right )}{ K_{Fru6P} \left ( 1 + \frac{Fru2,6BP}{Ka_{Fru2,6BP}} \right ) } \left [ 1 \frac{\frac{Fru6P \left ( 1 + \frac{Fru2,6BP}{\alpha Ka_{Fru2,6BP}} \right )}{ K_{Fru6P} \left ( 1 + \frac{Fru2,6BP}{Ka_{Fru2,6BP}} + \right ] } | ||
+ | |||
+ | {1} \right ) | ||
+ | |||
+ | \right) | ||
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Revision as of 15:34, 26 February 2014
The enzyme Phosphofructokinase Type-1 uses another ATP molecule to transfer a phosphate group to fructose 6-phosphate to form fructose 1, 6-bisphosphate. PFK-1 is an allosteric enzyme showing cooperative behaviour with Fru6P and hyperbolic kinetics with ATP.
Chemical equation
Rate equation
The concerted transition model of Monod, Wyman and Changeux (MWC model) is used as a rate equation for this tetrameric enzyme for considering exclusive ligand binding (F6P, activators and inhibitors) together with mixed type activation, (Fru2,6BP or AMP or Pi).