Difference between revisions of "Transformation of PGJ2 to 15-D-PGJ2"

From ISMOC
Jump to: navigation, search
 
(5 intermediate revisions by the same user not shown)
Line 1: Line 1:
 
[[Welcome to the In-Silico Model of Cutaneous Lipids Wiki | Return to overview]]
 
[[Welcome to the In-Silico Model of Cutaneous Lipids Wiki | Return to overview]]
 +
 +
In aqueous solutions containing serum albumin, PGJ2 is subject to an additional non-enzymatic dehydration reaction at the hydroxyl group of C15 to yield 15-deoxy-PGJ2. The products of these dehydration reactions have higher activity than the parent compound PGD2 <ref>Straus, D. S. Glass, C. K., ''Cyclopentenone prostaglandins: new insights on biological activities and cellular targets'', Med Res Rev (2001), 21, 185-210.</ref>.
 +
 
== Reaction ==
 
== Reaction ==
 +
[[File:R9_PGJ2_-_D15PGJ2.jpg|center|500px]]
  
 
==Chemical equation==
 
==Chemical equation==
Line 8: Line 12:
 
== Rate equation ==
 
== Rate equation ==
  
 +
[[File:R09.PNG|center|500px]]
  
 
== Parameters ==
 
== Parameters ==
 +
Note that the literature values are the same as [[Transformation of PGD2 to PGJ2 |reaction 8]].
 +
 +
===  Association Rate Constant (Kf) ===
 +
 +
{|class="wikitable sortable"
 +
|+  style="text-align: left;" | Literature values
 +
|-
 +
! Value
 +
! Units
 +
! Conditions
 +
! Substrate
 +
! Weight
 +
! Reference
 +
|-
 +
|3.3E+6 (excluded)
 +
|M-1 min-1
 +
|25°C and 0.055 ionic strength
 +
|H2CO3 to CO2
 +
|32
 +
|<ref name="Gibbons1963”>[http://www.jbc.org/content/238/10/3502.full.pdf B. Gibbons "Rate of Hydration of Carbon Dioxide and Dehydration of Carbonic Acid at 25" J Biol Chem. 1963 Oct;238:3502-7]</ref>
 +
|-
 +
|4.5
 +
|M-1 min-1
 +
|20°C
 +
|HC(OH)2COOH
 +
|32
 +
|<ref name="Turyan1998”>[hrcak.srce.hr/file/195437 Y.I. Tur'yan, "Kinetics and Equilibrium of the Dehydration-Hydration and Recombination-Dissociation Reactions of Glyoxylic Acid Investigated by Electrochemical Methods", CCACAA 71 (3) 727¿743 (1998)]</ref>
 +
|-
 +
|0.42
 +
|M-1 min-1
 +
|20°C
 +
|HC(OH)2COO–
 +
|32
 +
|<ref name="Turyan1998”>[hrcak.srce.hr/file/195437 Y.I. Tur'yan, "Kinetics and Equilibrium of the Dehydration-Hydration and Recombination-Dissociation Reactions of Glyoxylic Acid Investigated by Electrochemical Methods", CCACAA 71 (3) 727¿743 (1998)]</ref>
 +
|-
 +
|}
 +
 +
{| class="wikitable"
 +
|+  style="text-align: left;" | Description of the reaction 9 Kf distribution
 +
! Mode (M-1 s-1) !! Confidence Interval !! Location parameter (µ) !! Scale parameter (σ)
 +
|-
 +
| 4.48E+00 || 1.09E+03 || 7.34E+00 || 2.42E+00
 +
|}
 +
 +
[[Image:27.jpg|none|thumb|500px|The estimated probability distribution for reaction 9 Kf. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.  ]]
 +
 +
 +
=== Dissociation Rate Constant (Kr) ===
 +
This is a “Dependent parameter”, meaning that the log-normal distribution for this parameter was calculated using multivariate distributions  (this is discussed in detail[[Quantification of parameter uncertainty | here]]). As a result, no confidence interval factor or literature values were cited for this parameter.
 +
{| class="wikitable"
 +
|+  style="text-align: left;" | Description of the reaction 9 Kr distribution
 +
! Mode (M-1 s-1) !! Location parameter (µ) !! Scale parameter (σ)
 +
|-
 +
| 9.25E-04 || -6.07E+00 || 9.57E-01
 +
|-
 +
|}
 +
 +
[[Image:28.jpg|none|thumb|500px|The estimated probability distribution for reaction 9 Kr. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.  ]]
  
{|class="wikitable"  
+
===  Dissociation Constant ===
! Name
+
{|class="wikitable sortable"  
 +
|+  style="text-align: left;" | Literature values
 +
|-
 
! Value
 
! Value
 
! Units
 
! Units
! Species
+
! Conditions
 +
! Substrate
 +
! Weight
 
! Reference
 
! Reference
 
|-
 
|-
| X
+
|< 8E-04
| Y
+
|N/A
| Z
+
|OH Radicals in the Presence of Added Gas Phase HNO3 (3 ppmv n-pentadecane, 0.25, 0.50, 1.0, or 2.0 ppmv HNO3, 10 ppmv O3, and 2 ppmv TME were added from a glass bulb in a flow of N2)
| A
+
|Acid-Catalyzed Dehydration of Cyclic Hemiacetals (n-Pentadecane) in SOA
| B
+
[[File:Cyclic Hemiacetals.PNG ‎|center|100px]]
 +
|8
 +
|<ref name="Ranney2016”>[http://pubs.acs.org/doi/pdf/10.1021/acs.jpca.6b01402 A. Ranney "Kinetics of Acid-Catalyzed Dehydration of Cyclic Hemiacetals in Organic Aerosol Particles in Equilibrium with Nitric Acid Vapor"  J. Phys. Chem. A, 2016, 120 (16), pp 2561–2568]</ref>
 +
|-
 +
|4E-04
 +
|N/A
 +
|PH of 100 cc. 0-02N NaHCO3, saturated with C02, into which 0 95 cc.
 +
|H2CO3
 +
|8
 +
|<ref name="BUYTENDYK1927”>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1251954/pdf/biochemj01144-0128.pdf F. BUYTENDYK "A Study of the System Carbonic Acid, Carbon Dioxide and Water - Determination of the True Dissociation-constant of Carbonic Acid"  Biochem J. 1927; 21(3): 576–584.]</ref>
 +
|-
 +
|4.4E-4
 +
|N/A
 +
|In a 0O008 mol. solution of carbonic acid at 4°, 1-23 % is present as H2CO3
 +
|H2CO3
 +
|8
 +
|<ref name="Thiel1914”>[http://onlinelibrary.wiley.com/doi/10.1002/cber.191404701173/epdf Thiel and Strohecker (1914). Ber. deutsch. chem. Gem. 47, 945, 1061.]</ref>
 +
|-
 
|}
 
|}
 +
 +
{| class="wikitable"
 +
|+  style="text-align: left;" | Description of the reaction 9 KD distribution
 +
! Mode (M-1 s-1) !! Confidence Interval !! Location parameter (µ) !! Scale parameter (σ)
 +
|-
 +
| 4.49E-04 || 1.38E+00 || -7.61E+00 || 3.07E-01
 +
|-
 +
|}
 +
 +
[[Image:R9 kd.jpg|none|thumb|500px|The estimated probability distribution for reaction 9 KD. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.  ]]
  
 
== Related Reactions ==
 
== Related Reactions ==
 
* [[Transformation of PGD2 to PGJ2 |Transformation of PGD2 to PGJ2]]
 
* [[Transformation of PGD2 to PGJ2 |Transformation of PGD2 to PGJ2]]

Latest revision as of 08:11, 21 August 2019

Return to overview

In aqueous solutions containing serum albumin, PGJ2 is subject to an additional non-enzymatic dehydration reaction at the hydroxyl group of C15 to yield 15-deoxy-PGJ2. The products of these dehydration reactions have higher activity than the parent compound PGD2 [1].

Reaction

R9 PGJ2 - D15PGJ2.jpg

Chemical equation

 FA \rightleftharpoons AA

Rate equation

R09.PNG

Parameters

Note that the literature values are the same as reaction 8.

Association Rate Constant (Kf)

Literature values
Value Units Conditions Substrate Weight Reference
3.3E+6 (excluded) M-1 min-1 25°C and 0.055 ionic strength H2CO3 to CO2 32 [2]
4.5 M-1 min-1 20°C HC(OH)2COOH 32 [3]
0.42 M-1 min-1 20°C HC(OH)2COO– 32 [3]
Description of the reaction 9 Kf distribution
Mode (M-1 s-1) Confidence Interval Location parameter (µ) Scale parameter (σ)
4.48E+00 1.09E+03 7.34E+00 2.42E+00
The estimated probability distribution for reaction 9 Kf. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.


Dissociation Rate Constant (Kr)

This is a “Dependent parameter”, meaning that the log-normal distribution for this parameter was calculated using multivariate distributions (this is discussed in detail here). As a result, no confidence interval factor or literature values were cited for this parameter.

Description of the reaction 9 Kr distribution
Mode (M-1 s-1) Location parameter (µ) Scale parameter (σ)
9.25E-04 -6.07E+00 9.57E-01
The estimated probability distribution for reaction 9 Kr. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.

Dissociation Constant

Literature values
Value Units Conditions Substrate Weight Reference
< 8E-04 N/A OH Radicals in the Presence of Added Gas Phase HNO3 (3 ppmv n-pentadecane, 0.25, 0.50, 1.0, or 2.0 ppmv HNO3, 10 ppmv O3, and 2 ppmv TME were added from a glass bulb in a flow of N2) Acid-Catalyzed Dehydration of Cyclic Hemiacetals (n-Pentadecane) in SOA
Cyclic Hemiacetals.PNG
8 [4]
4E-04 N/A PH of 100 cc. 0-02N NaHCO3, saturated with C02, into which 0 95 cc. H2CO3 8 [5]
4.4E-4 N/A In a 0O008 mol. solution of carbonic acid at 4°, 1-23 % is present as H2CO3 H2CO3 8 [6]
Description of the reaction 9 KD distribution
Mode (M-1 s-1) Confidence Interval Location parameter (µ) Scale parameter (σ)
4.49E-04 1.38E+00 -7.61E+00 3.07E-01
The estimated probability distribution for reaction 9 KD. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.

Related Reactions

  • Straus, D. S. Glass, C. K., Cyclopentenone prostaglandins: new insights on biological activities and cellular targets, Med Res Rev (2001), 21, 185-210.
  • B. Gibbons "Rate of Hydration of Carbon Dioxide and Dehydration of Carbonic Acid at 25" J Biol Chem. 1963 Oct;238:3502-7
  • 3.0 3.1 [hrcak.srce.hr/file/195437 Y.I. Tur'yan, "Kinetics and Equilibrium of the Dehydration-Hydration and Recombination-Dissociation Reactions of Glyoxylic Acid Investigated by Electrochemical Methods", CCACAA 71 (3) 727¿743 (1998)]
  • A. Ranney "Kinetics of Acid-Catalyzed Dehydration of Cyclic Hemiacetals in Organic Aerosol Particles in Equilibrium with Nitric Acid Vapor" J. Phys. Chem. A, 2016, 120 (16), pp 2561–2568
  • F. BUYTENDYK "A Study of the System Carbonic Acid, Carbon Dioxide and Water - Determination of the True Dissociation-constant of Carbonic Acid" Biochem J. 1927; 21(3): 576–584.
  • Thiel and Strohecker (1914). Ber. deutsch. chem. Gem. 47, 945, 1061.
  • Retrieved from ‘http://www.systemsbiology.ls.manchester.ac.uk/wiki/index.php?title=Transformation_of_PGJ2_to_15-D-PGJ2&oldid=7479