Difference between revisions of "Transformation of PGD2 to PGJ2"

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[[Welcome to the In-Silico Model of Cutaneous Lipids Wiki | Return to overview]]
 
[[Welcome to the In-Silico Model of Cutaneous Lipids Wiki | Return to overview]]
  
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Due to the lack of PGD2 production by keratinocyte and fibroblast cells, the anti-inflammatory cyclopentanones, PGJ2 and 15d-PGJ2, will not be produced during early experimental procedures either.  
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PGD2 is subsequently converted to PGJ2 via a non-enzymatic dehydration reaction <ref>Fitzpatrick, F. A. Wynalda, M. A., ''Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro'', J Biol Chem (1983), 258, 11713-8.</ref>. This dehydration reaction takes place in an aqueous solution and includes the removal of two hydrogens and one oxygen molecule. This reaction occurs across the C9 hydroxyl and the C10 carbon axis, to form a double bond between C9 and 10.  
  
  
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! Conditions
 
! Conditions
 
! Substrate
 
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! Weight
 
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|25°C and 0.055 ionic strength
 
|25°C and 0.055 ionic strength
 
|H2CO3 to CO2
 
|H2CO3 to CO2
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|32
 
|<ref name="Gibbons1963”>[http://www.jbc.org/content/238/10/3502.full.pdf B. Gibbons "Rate of Hydration of Carbon Dioxide and Dehydration of Carbonic Acid at 25" J Biol Chem. 1963 Oct;238:3502-7]</ref>
 
|<ref name="Gibbons1963”>[http://www.jbc.org/content/238/10/3502.full.pdf B. Gibbons "Rate of Hydration of Carbon Dioxide and Dehydration of Carbonic Acid at 25" J Biol Chem. 1963 Oct;238:3502-7]</ref>
 
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|20°C
 
|20°C
 
|HC(OH)2COOH
 
|HC(OH)2COOH
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|32
 
|<ref name="Turyan1998”>[hrcak.srce.hr/file/195437 Y.I. Tur'yan, "Kinetics and Equilibrium of the Dehydration-Hydration and Recombination-Dissociation Reactions of Glyoxylic Acid Investigated by Electrochemical Methods", CCACAA 71 (3) 727¿743 (1998)]</ref>
 
|<ref name="Turyan1998”>[hrcak.srce.hr/file/195437 Y.I. Tur'yan, "Kinetics and Equilibrium of the Dehydration-Hydration and Recombination-Dissociation Reactions of Glyoxylic Acid Investigated by Electrochemical Methods", CCACAA 71 (3) 727¿743 (1998)]</ref>
 
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|20°C
 
|20°C
 
|HC(OH)2COO–
 
|HC(OH)2COO–
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|32
 
|<ref name="Turyan1998”>[hrcak.srce.hr/file/195437 Y.I. Tur'yan, "Kinetics and Equilibrium of the Dehydration-Hydration and Recombination-Dissociation Reactions of Glyoxylic Acid Investigated by Electrochemical Methods", CCACAA 71 (3) 727¿743 (1998)]</ref>
 
|<ref name="Turyan1998”>[hrcak.srce.hr/file/195437 Y.I. Tur'yan, "Kinetics and Equilibrium of the Dehydration-Hydration and Recombination-Dissociation Reactions of Glyoxylic Acid Investigated by Electrochemical Methods", CCACAA 71 (3) 727¿743 (1998)]</ref>
 
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[[Image:26.jpg|none|thumb|500px|The estimated probability distribution for reaction 8 Kf. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.  ]]
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[[Image:26.jpg|none|thumb|500px|The estimated probability distribution for reaction 8 Kr. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.  ]]
  
 
===  Dissociation Constant ===
 
===  Dissociation Constant ===
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! Conditions
 
! Conditions
 
! Substrate
 
! Substrate
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! Weight
 
! Reference
 
! Reference
 
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|Acid-Catalyzed Dehydration of Cyclic Hemiacetals (n-Pentadecane) in SOA
 
|Acid-Catalyzed Dehydration of Cyclic Hemiacetals (n-Pentadecane) in SOA
 
[[File:Cyclic Hemiacetals.PNG ‎|center|100px]]
 
[[File:Cyclic Hemiacetals.PNG ‎|center|100px]]
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|8
 
|<ref name="Ranney2016”>[http://pubs.acs.org/doi/pdf/10.1021/acs.jpca.6b01402 A. Ranney "Kinetics of Acid-Catalyzed Dehydration of Cyclic Hemiacetals in Organic Aerosol Particles in Equilibrium with Nitric Acid Vapor"  J. Phys. Chem. A, 2016, 120 (16), pp 2561–2568]</ref>
 
|<ref name="Ranney2016”>[http://pubs.acs.org/doi/pdf/10.1021/acs.jpca.6b01402 A. Ranney "Kinetics of Acid-Catalyzed Dehydration of Cyclic Hemiacetals in Organic Aerosol Particles in Equilibrium with Nitric Acid Vapor"  J. Phys. Chem. A, 2016, 120 (16), pp 2561–2568]</ref>
 
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|PH of 100 cc. 0-02N NaHCO3, saturated with C02, into which 0 95 cc.
 
|PH of 100 cc. 0-02N NaHCO3, saturated with C02, into which 0 95 cc.
 
|H2CO3
 
|H2CO3
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|8
 
|<ref name="BUYTENDYK1927”>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1251954/pdf/biochemj01144-0128.pdf F. BUYTENDYK "A Study of the System Carbonic Acid, Carbon Dioxide and Water - Determination of the True Dissociation-constant of Carbonic Acid"  Biochem J. 1927; 21(3): 576–584.]</ref>
 
|<ref name="BUYTENDYK1927”>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1251954/pdf/biochemj01144-0128.pdf F. BUYTENDYK "A Study of the System Carbonic Acid, Carbon Dioxide and Water - Determination of the True Dissociation-constant of Carbonic Acid"  Biochem J. 1927; 21(3): 576–584.]</ref>
 
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|In a 0O008 mol. solution of carbonic acid at 4°, 1-23 % is present as H2CO3
 
|In a 0O008 mol. solution of carbonic acid at 4°, 1-23 % is present as H2CO3
 
|H2CO3
 
|H2CO3
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|8
 
|<ref name="Thiel1914”>[http://onlinelibrary.wiley.com/doi/10.1002/cber.191404701173/epdf Thiel and Strohecker (1914). Ber. deutsch. chem. Gem. 47, 945, 1061.]</ref>
 
|<ref name="Thiel1914”>[http://onlinelibrary.wiley.com/doi/10.1002/cber.191404701173/epdf Thiel and Strohecker (1914). Ber. deutsch. chem. Gem. 47, 945, 1061.]</ref>
 
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[[Image:R8 kd.jpg|none|thumb|500px|The estimated probability distribution for reaction 8 Kf. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.  ]]
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[[Image:R8 kd.jpg|none|thumb|500px|The estimated probability distribution for reaction 8 KD. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.  ]]
  
 
== Related Reactions ==
 
== Related Reactions ==

Latest revision as of 08:09, 21 August 2019

Return to overview

PGD2 is subsequently converted to PGJ2 via a non-enzymatic dehydration reaction [1]. This dehydration reaction takes place in an aqueous solution and includes the removal of two hydrogens and one oxygen molecule. This reaction occurs across the C9 hydroxyl and the C10 carbon axis, to form a double bond between C9 and 10.


Reaction

R8 PGD2 - PGJ2.jpg

Chemical equation

PGD2\rightleftharpoons PGJ2

Rate equation

R08.PNG

Parameters

Association Rate Constant (Kf)

Literature values
Value Units Conditions Substrate Weight Reference
3.3E+6 (excluded) M-1 min-1 25°C and 0.055 ionic strength H2CO3 to CO2 32 [2]
4.5 M-1 min-1 20°C HC(OH)2COOH 32 [3]
0.42 M-1 min-1 20°C HC(OH)2COO– 32 [3]
Description of the reaction 8 Kf distribution
Mode (M-1 s-1) Confidence Interval Location parameter (µ) Scale parameter (σ)
4.48E+00 1.09E+03 7.34E+00 2.42E+00
The estimated probability distribution for reaction 8 Kf. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.


Dissociation Rate Constant (Kr)

This is a “Dependent parameter”, meaning that the log-normal distribution for this parameter was calculated using multivariate distributions (this is discussed in detail here). As a result, no confidence interval factor or literature values were cited for this parameter.

Description of the reaction 8 Kr distribution
Mode (M-1 s-1) Location parameter (µ) Scale parameter (σ)
9.25E-04 -6.07E+00 9.57E-01
The estimated probability distribution for reaction 8 Kr. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.

Dissociation Constant

Literature values
Value Units Conditions Substrate Weight Reference
< 8E-04 N/A OH Radicals in the Presence of Added Gas Phase HNO3 (3 ppmv n-pentadecane, 0.25, 0.50, 1.0, or 2.0 ppmv HNO3, 10 ppmv O3, and 2 ppmv TME were added from a glass bulb in a flow of N2) Acid-Catalyzed Dehydration of Cyclic Hemiacetals (n-Pentadecane) in SOA
Cyclic Hemiacetals.PNG
 8 [4]
4E-04 N/A PH of 100 cc. 0-02N NaHCO3, saturated with C02, into which 0 95 cc. H2CO3 8 [5]
4.4E-4 N/A In a 0O008 mol. solution of carbonic acid at 4°, 1-23 % is present as H2CO3 H2CO3 8 [6]
Description of the reaction 8 KD distribution
Mode (M-1 s-1) Confidence Interval Location parameter (µ) Scale parameter (σ)
4.49E-04 1.38E+00 -7.61E+00 3.07E-01
The estimated probability distribution for reaction 8 KD. The value and weight of the literature values used to define the distribution are indicated by an orange dashed line. The x axis is plotted on a log-scale.

Related Reactions

References

  1. ↑ Fitzpatrick, F. A. Wynalda, M. A., Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro, J Biol Chem (1983), 258, 11713-8.
  2. ↑ B. Gibbons "Rate of Hydration of Carbon Dioxide and Dehydration of Carbonic Acid at 25" J Biol Chem. 1963 Oct;238:3502-7
  3. ↑ 3.0 3.1 [hrcak.srce.hr/file/195437 Y.I. Tur'yan, "Kinetics and Equilibrium of the Dehydration-Hydration and Recombination-Dissociation Reactions of Glyoxylic Acid Investigated by Electrochemical Methods", CCACAA 71 (3) 727¿743 (1998)]
  4. ↑ A. Ranney "Kinetics of Acid-Catalyzed Dehydration of Cyclic Hemiacetals in Organic Aerosol Particles in Equilibrium with Nitric Acid Vapor" J. Phys. Chem. A, 2016, 120 (16), pp 2561–2568
  5. ↑ F. BUYTENDYK "A Study of the System Carbonic Acid, Carbon Dioxide and Water - Determination of the True Dissociation-constant of Carbonic Acid" Biochem J. 1927; 21(3): 576–584.
  6. ↑ Thiel and Strohecker (1914). Ber. deutsch. chem. Gem. 47, 945, 1061.
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