View source for Transformation of PGH2 to PGE2

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== Reaction ==
[[File:R10_PGH2_-_PGE2.jpg|center|500px]]

==Chemical equation==

<center><math> FA \rightleftharpoons AA </math></center>

== Rate equation ==


== Parameters ==

{|class="wikitable sortable" 
|+  style="text-align: left;" | Michaelis-Menten Constants 
|-
! Value
! Units
! Species
! Notes
! Reference
|-
|1.6E-01 ± 4.00E-03
|<math> mM </math>
|Human 
|Synovial Tissue
|<ref name="Pettersson2005"> [http://www.ncbi.nlm.nih.gov/pubmed/16399384 Pettersson P. , "Identification of beta-trace as prostaglandin D synthase.'' FASEB J. 2010 Dec;24(12):4668-77. doi: 10.1096/fj.10-164863. Epub 2010 Jul 28.]</ref>  
|-
|2.15E-01
|<math> mM </math>
|Human 
|Wild Type Enzyme
|<ref name="Hamza2010"> [http://www.ncbi.nlm.nih.gov/pubmed/20369883 Hamza A. , "Understanding microscopic binding of human microsomal prostaglandin E synthase-1 (mPGES-1) trimer with substrate PGH2 and cofactor GSH: insights from computational alanine scanning and site-directed mutagenesis.'' J Phys Chem B. 2010 Apr 29;114(16):5605-16. doi: 10.1021/jp100668y.]</ref>
|-
|1.49E-02
|<math> mM </math>
|Human 
|cPGES, casein kinase II and Hsp90 
|<ref name="Kobayashi04"> [http://www.ncbi.nlm.nih.gov/pubmed/15040786 Kobayashi T. , "Regulation of cytosolic prostaglandin E synthase by phosphorylation.'' Biochem J. 2004 Jul 1;381(Pt 1):59-69.]</ref>  
|-
|6.66E-02
|<math> mM </math>
|Human
|cPGES
|<ref name="Kobayashi04"></ref>  
|-
|}

{|class="wikitable sortable" 
|+  style="text-align: left;" | Enzyme Turnover Numbers
|-
! Value
! Units
! Species
! Notes
! Reference
|-
| X
| Y
| Z
| A
| B
|}

== References ==
<references/>


== Related Reactions ==

* [[Transformation of AA to PGH2 |Transformation of AA to PGH2]]