Difference between revisions of "Translation of R"
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− | |<math>0.88</math> <ref name="Cox2004"> Cox RA. ''Quantitative relationships for specific growth rates and macromolecular compositions of Mycobacterium tuberculosis, Streptomyces coelicolor A3(2) and Escherichia coli B/r: an integrative theoretical approach.'' Microbiology. 2004 May;150(Pt 5):1413-26. </ref> | + | |<math>0.88</math> <ref name="Cox2004"> Cox RA. ''Quantitative relationships for specific growth rates and macromolecular compositions of Mycobacterium tuberculosis, Streptomyces coelicolor A3(2) and Escherichia coli B/r: an integrative theoretical approach.'' Microbiology. 2004 May;150(Pt 5):1413-26. </ref> For scbR the initiation rate is 5 <math> min^{-1} </math> and the elongation rate is (648/3-1 aa/gene)/(14 aa/<math>s^{-1}</math>)= , thus resulting in a final value of 0.88 <math> min^{-1} </math>. |
+ | Since the elongation is slower than the initiation, we conclude that it is the limiting step. | ||
|<math> min^{-1} </math> | |<math> min^{-1} </math> | ||
| ''Streptomyces coelicolor'' A3(2) | | ''Streptomyces coelicolor'' A3(2) |
Revision as of 09:53, 5 October 2015
The scbR mRNA (r) is translated into ScbR protein (R).
Contents
Chemical equation
Rate equation
Parameters
The parameter of this reaction is the translation rate of ScbR ().
Name | Value | Units | Origin | Remarks |
---|---|---|---|---|
Failed to parse (Cannot store math image on filesystem.): 0.88
[1] For scbR the initiation rate is 5 and the elongation rate is (648/3-1 aa/gene)/(14 aa/Failed to parse (Cannot store math image on filesystem.): s^{-1}
)= , thus resulting in a final value of 0.88 .
Since the elongation is slower than the initiation, we conclude that it is the limiting step. |
Streptomyces coelicolor A3(2) | Translation values were calculated according to the rates proposed in the paper by R.A. Cox using the basepairs for each gene. |
Parameters with uncertainty
The most plausible parameter value for the is decided to be Failed to parse (Cannot store math image on filesystem.): 0.5 min^{-1} and the confidence interval . This means that the mode of the PDF is 0.5 and the range where 95% of the values are found is between 0.05 and 5 .
The probability distribution for the parameter, adjusted accordingly in order to reflect the above values, is the following:
The location and scale parameters of the distribution are:
Parameter | μ | σ |
---|---|---|
Failed to parse (Cannot store math image on filesystem.): 0.1220 |
References
- ↑ Cox RA. Quantitative relationships for specific growth rates and macromolecular compositions of Mycobacterium tuberculosis, Streptomyces coelicolor A3(2) and Escherichia coli B/r: an integrative theoretical approach. Microbiology. 2004 May;150(Pt 5):1413-26.