Difference between revisions of "Transformation of TXA2 to TXB2"
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Thromboxane A2 is a bioactive molecule which affects vasoactivity and promotes thrombosis. It is unstable due to the epoxide functional group, and as a consequence has a short half-life of 20- 30 seconds. The hydrolysis reaction results in the generation of biologically inactive TXB2. | Thromboxane A2 is a bioactive molecule which affects vasoactivity and promotes thrombosis. It is unstable due to the epoxide functional group, and as a consequence has a short half-life of 20- 30 seconds. The hydrolysis reaction results in the generation of biologically inactive TXB2. | ||
Revision as of 11:24, 5 September 2016
Thromboxane A2 is a bioactive molecule which affects vasoactivity and promotes thrombosis. It is unstable due to the epoxide functional group, and as a consequence has a short half-life of 20- 30 seconds. The hydrolysis reaction results in the generation of biologically inactive TXB2.
Contents
Reaction
Chemical equation
Rate equation
Parameters
| Value | Units | Conditions | Substrate | Reference |
|---|---|---|---|---|
| 3.7e3 ± 0.1e3 | M-1 s-1 | NaCl04 (0.1 - 0.2 M)
Temperature: 25°C |
3 | [1] |
| 8.7e3 | M-1 s-1 | KCl (1 M)
Temperature: 25°C |
3 | [1] |
| 1.1e4 ± 0.1e4 | M-1 s-1 | NaCl04 (0.1 - 0.2 M)
Temperature: 25°C |
4 | [1] |
| 2.4 e4 | M-1 s-1 | KCl (1M)
Temperature: 25°C |
4 | [1] |
| 3.7e3 ± 0.1e3 | M-1 s-1 | NaCl04 (0.1 - 0.2 M)
Temperature: 25°C |
5 | [1] |
| 3.6 ± 0.2 | M-1 s-1 | NaCl04 (0.1 - 0.2 M)
Temperature: 25°C |
6 | [1] |
| 1.7 ± 0.1 | M-1 s-1 | NaCl04 (0.1 - 0.2 M)
Temperature: 25°C |
7 | [1] |
| 26.7 ± 0.9 | M-1 s-1 | NaCl04 (0.1 - 0.2 M)
Temperature: 25°C |
8 | [1] |
| 35 | M-1 s-1 | KCl (1M)
Temperature: 25°C |
8 | [1] |
