Transformation of PGH2 to TXA2

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Reaction

R4 PGH2 -TXA4.jpg

Chemical equation

FA \rightleftharpoons AA

Rate equation

Parameters

Michaelis-Menten Constants
Value Units Species Notes Reference
4.00E-03 mM Human PMN [1]
4.00E-03 mM Human Platelet Free Human Monocyte [2]
1.00E-02 mM Human Human Thromboxane Synthase [3]
2.20E-02 mM Human Wild-Type TXAS [4]
Enzyme Turnover Numbers
Value Units Species Notes Reference
1599 Failed to parse (Cannot store math image on filesystem.): min{-1} Human PMN [1]

References

  1. ↑ 1.0 1.1 Yang K. “Finding multiple target optimal intervention in disease-related molecular network.” Mol Syst Biol 2008, (4):228
  2. ↑ M. Orlandi, G. Bartolini, Thromboxane A2 synthase activity in platelet free human monocytes. Biochim Biophys Acta. 1994 Dec 8;1215(3):285-90.
  3. ↑ R. Nusing, S. Schneider-Voss and V. Ullrich, Immunoaffinity purification of human thromboxane synthase. Arch Biochem Biophys. 1990 Aug 1;280(2):325-30.
  4. ↑ Hecker M. On the mechanism of prostacyclin and thromboxane A2 biosynthesis.J Biol Chem. 1989 Jan 5;264(1):141-50.

Related Reactions

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