Difference between revisions of "Transformation of PGH2 to TXA2"

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(Parameters)
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! Reference
 
! Reference
 
|-
 
|-
| X
+
|4.00E-03
| Y
+
|<math> mM </math>
| Z
+
|Human
| A
+
|PMN
| B
+
|<ref name="Yang2008”>[http://www.ncbi.nlm.nih.gov/pubmed/18985027 Yang K. “Finding multiple target optimal intervention in disease-related molecular network.” Mol Syst Biol 2008, (4):228]</ref> 
 +
|-
 +
|4.00E-03
 +
|<math> mM </math>
 +
|Human
 +
|Platelet Free Human Monocyte
 +
|<ref name="Orlandi1994"> [http://www.ncbi.nlm.nih.gov/pubmed/7811713 M. Orlandi, G. Bartolini, Thromboxane A2 synthase activity in platelet free human monocytes.'' Biochim Biophys Acta. 1994 Dec 8;1215(3):285-90.]</ref> 
 +
|-
 +
|1.00E-02
 +
|<math> mM </math>
 +
|Human
 +
|Human Thromboxane Synthase
 +
|<ref name="Nusing1989"> [http://www.ncbi.nlm.nih.gov/pubmed/2195994 R. Nusing, S. Schneider-Voss and V. Ullrich, Immunoaffinity purification of human thromboxane synthase.'' Arch Biochem Biophys. 1990 Aug 1;280(2):325-30.]</ref>
 +
|-
 +
|<math>Km</math>
 +
|2.20E-02
 +
|<math> mM </math>
 +
|Human
 +
|Wild-Type TXAS
 +
|<ref name="Hecker1989"> [http://www.ncbi.nlm.nih.gov/pubmed/2491846 Hecker M.  ''On the mechanism of prostacyclin and thromboxane A2 biosynthesis.''J Biol Chem. 1989 Jan 5;264(1):141-50.]</ref> 
 +
|-
 
|}
 
|}
  
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! Reference
 
! Reference
 
|-
 
|-
| X
+
|1599
| Y
+
|<math> min{-1} </math>
| Z
+
|Human
| A
+
|PMN
| B
+
|<ref name="Yang2008”>[http://www.ncbi.nlm.nih.gov/pubmed/18985027 Yang K. “Finding multiple target optimal intervention in disease-related molecular network.” Mol Syst Biol 2008, (4):228]</ref> 
 +
|-
 
|}
 
|}
 +
 +
== References ==
 +
<references/>
  
 
== Related Reactions ==
 
== Related Reactions ==
 
* [[Transformation of AA to PGH2 |Transformation of AA to PGH2]]  
 
* [[Transformation of AA to PGH2 |Transformation of AA to PGH2]]  
 
* [[Transformation of TXA2 to TXB2 |Transformation of TXA2 to TXB2]]
 
* [[Transformation of TXA2 to TXB2 |Transformation of TXA2 to TXB2]]

Revision as of 13:23, 8 April 2016

Return to overview

Reaction

R4 PGH2 -TXA4.jpg

Chemical equation

 FA \rightleftharpoons AA

Rate equation

Parameters

Michaelis-Menten Constants
Value Units Species Notes Reference
4.00E-03  mM Human PMN [1]
4.00E-03  mM Human Platelet Free Human Monocyte [2]
1.00E-02  mM Human Human Thromboxane Synthase [3]
Failed to parse (Cannot store math image on filesystem.): Km 2.20E-02  mM Human Wild-Type TXAS [4]
Enzyme Turnover Numbers
Value Units Species Notes Reference
1599 Failed to parse (Cannot store math image on filesystem.): min{-1} Human PMN [1]

References

Related Reactions