Transformation of PGH2 to PGI2

Reaction

FA \rightleftharpoons AA

Michaelis-Menten Constants
Value	Units	Species	Notes	Reference
1.33E-02 ± 1.40E-03	$mM$	Human	Expression Vector: Bovine Endothelial and Aorta Cells Enzyme: Human PGIS pH:7.4 Temperature: 23	^[1]
9.00E-03 ± 5.00E-03	$mM$	Bovine	Expression Vector: Bovine Endothelial and Aorta Cells Enzyme: Bovine PGIS pH:7.4 Temperature: 24	^[2]

Enzyme Turnover Numbers
Value	Units	Species	Notes	Reference
147 ± 45	per minute	Cattle	Expression Vector: E. Coli Enzyme: Bovine PGIS pH:7.4 Temperature: 24	^[2]

PGIS Abundance
Value	Units	Species	Notes	Reference
412	$ppm$	Human	Expression Vector: Urinary bladder Enzyme: PGIS pH: 7.5 Temperature: 37 °C	^[3]
206	$ppm$	Human	Expression Vector: Lung Enzyme: PGIS pH: 7.5 Temperature: 37 °C	^[3]
60.1	$ppm$	Human	Expression Vector: Esophagus Enzyme: PGIS pH: 7.5 Temperature: 37 °C	^[3]
9.93	$ppm$	Human	Expression Vector: Oral Cavity Enzyme: PGIS pH: 7.5 Temperature: 37 °C	^[4]

Gibbs Free Energy Change
Value	Units	Species	Notes	Reference
0.04	kcal/mol	Not stated	Estimated Enzyme: pgis Substrate: Arachidonate Product: PGI2 pH: 7.3 ionic strength: 0.25	^[5]