Transformation of LTA4 to LTB4
Reaction
Chemical equation
Rate equation
Parameters
| Value | Units | Species | Notes | Reference |
|---|---|---|---|---|
| 5.80E-03 | mM | Human | Wild Type, pH 8.0, at room temperature. | [1] |
| 2.70E-03 | mM | Human | Leukocytes, pH 8.0 at room temperature. | [2] |
| 2.20E-02 | mM | Human | 2°C, pH 8.0 | [3] |
| 2.30E-03 | 37°C, pH 8.0 |
| Value | Units | Species | Notes | Reference |
|---|---|---|---|---|
| 12.6 - 28.2 | per minute | Human | Wild type enzyme, pH 7.4, 37 °C. | [4] |
| 51 | per minute | Human | Wild Type, pH 8.0, at room temperature. | [1] |
| 90 | per minute | Human | Leukocytes, pH 8.0 at room temperature. | [2] |
| 125 | per minute | Human | Leukcyte pH 8.0, 37 °C | [3] |
Related Reactions
- ↑ 1.0 1.1 [www.ncbi.nlm.nih.gov/pubmed/8650196 Mueller M. , "Leukotriene A4 hydrolase: protection from mechanism-based inactivation by mutation of tyrosine-378. Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5931-5.]
- ↑ 2.0 2.1 [www.ncbi.nlm.nih.gov/pubmed/9744798 Stromberg F. , "Purification and characterization of leukotriene A4 hydrolase from Xenopus laevis oocytes. FEBS Lett. 1998 Aug 21;433(3):219-22.]
- ↑ 3.0 3.1 [www.ncbi.nlm.nih.gov/pubmed/6490615 Radmark O. , "Leukotriene A4 hydrolase in human leukocytes. Purification and properties J Biol Chem. 1984 Oct 25;259(20):12339-45.]
- ↑ [www.ncbi.nlm.nih.gov/pubmed/11675384 Rudberg P. , "Leukotriene A4 Hydrolase/Aminopeptidase The Journal of Biological Chemistry, 277, 1398-1404.]
