Transformation of AA to 5-HPETE

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Reaction

R11 AA - HPETE5.jpg

Chemical equation

AA \rightleftharpoons PGH2

Rate equation

5-LOX Parameters

Michaelis-Menten Constants
Value Units Species Notes Reference
5.10E-03 mM Human Recombinant 5-Lipoxygenase [1]
1.20E-02 mM Human PMN Leukocyte [2]
6.31E-02 mM Human Polymorphonuclear Leukocytes [3]
Enzyme Turnover Numbers
Value Units Species Notes Reference
1500 + 75 per minute Potato Potato Tubers, pH 5.5, [4]

References

  1. ↑ Shirumalla R. K. “RBx 7,796: A novel inhibitor of 5-lipoxygenase.” Inflamm Res. 2006 Dec ; 55 (12) : 517-27.
  2. ↑ Soberman R. J. "5- and 15(omega-6)-lipoxygenases from human polymorphonuclear leukocytes. Methods Enzymol. 1988; 163:344-9.
  3. ↑ Soberman R. J. “Characterization and separation of the arachidonic acid 5-lipoxygenase and linoleic acid omega-6 lipoxygenase (arachidonic acid 15-lipoxygenase) of human polymorphonuclear leukocytes.” J Biol Chem. 1985 Apr 10;260(7):4508-15.
  4. ↑ Mulliez E., “5-Lipoxygenase from potato tubers. Improved purification and physicochemical characteristics” Biochimica et Biophysica Acta, 1987;916(1):13-23.


Related Reactions

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