Transformation of AA to 15-HPETE

From ISMOC
Revision as of 13:51, 8 April 2016 by Muttley93 (talk | contribs) (→‎Parameters)
Jump to: navigation, search

Return to overview

Reaction

R17 AA - HPETE15.jpg

Chemical equation

AA \rightleftharpoons PGH2

Rate equation

Parameters

Michaelis-Menten Constants
Value Units Species Notes Reference
3.70E-03 ± 3.00E-04 mM Human Epithelium [1]
5.00E-03 mM Human Reticulocyte [2]
1.06E-02 mM Human Keratinocyte [3]
1.17E-02 ± 9.00E-04 mM Human Wildtype 15-Lipoxygenase [4]
Enzyme Turnover Numbers
Value Units Species Notes Reference
9.93 ± 0.28 Failed to parse (Cannot store math image on filesystem.): s^{-1} Human Epithelium [1]

References

  1. ↑ 1.0 1.1 Jacquot C. "Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases. Biochemistry. 2008 Jul 8;47(27):7295-303. doi: 10.1021/bi800308q. Epub 2008 Jun 12.
  2. ↑ Jacquot C. "Synthesis of 11-Thialinoleic Acid and 14-Thialinoleic Acid, Inhibitors of Soybean and Human Lipoxygenases Org Biomol Chem. 2008 Nov 21; 6(22): 4242–4252.
  3. ↑ Burrall B. "Enzymatic properties of the 15-lipoxygenase of human cultured keratinocytes. J Invest Dermatol. 1988 Oct;91(4):294-7.
  4. ↑ Sloane D. L. "Conversion of human 15-lipoxygenase to an efficient 12-lipoxygenase: the side-chain geometry of amino acids 417 and 418 determine positional specificity. Protein Eng. 1995 Mar;8(3):275-82..

Related Reactions

Retrieved from ‘http://www.systemsbiology.ls.manchester.ac.uk/wiki/index.php?title=Transformation_of_AA_to_15-HPETE&oldid=4342’