Difference between revisions of "Transformation of AA to 15-HPETE"

Revision as of 18:03, 10 April 2016

AA \rightleftharpoons PGH2

Michaelis-Menten Constants
Value	Units	Species	Notes	Reference
3.70E-03 ± 3.00E-04	$mM$	Human	Epithelium	^[1]
5.00E-03	$mM$	Human	Reticulocyte	^[2]
1.06E-02	$mM$	Human	Keratinocyte	^[3]
1.17E-02 ± 9.00E-04	$mM$	Human	Wildtype 15-Lipoxygenase	^[4]

Enzyme Turnover Numbers
Value	Units	Species	Notes	Reference
595.8 ± 16.8	$minute^{-1}$	Human	Epithelium	^[1]
37.2 ± 1.8	per minute	Human	pH 7	^[5]
45 ± 1.2			pH 7.5
44.4 ± 2.4			pH 8

@@ Line 57: / Line 57: @@
 ! Reference
 |-
-|9.93 ± 0.28
+|595.8 ± 16.8
-|<math> s^{-1} </math>
+|<math> minute^{-1} </math>
 |Human
 |Epithelium
 |<ref name="Jacquot2008"> [http://www.ncbi.nlm.nih.gov/pubmed/18547056 Jacquot C. "Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases.'' Biochemistry. 2008 Jul 8;47(27):7295-303. doi: 10.1021/bi800308q. Epub 2008 Jun 12.]</ref>
+|-
+|37.2 ± 1.8
+|rowspan="3"|per minute
+|rowspan="3"|Human
+|pH 7
+|rowspan="3"|<ref name="Wecksler2009"> [http://www.ncbi.nlm.nih.gov/pubmed/18547056 Jacquot C. "Kinetic and Structural Investigations of the Allosteric Site in Human Epithelial 15-Lipoxygenase-2'' Biochemistry, 2009, 48 (36), pp 8721–8730]</ref>
+|-
+|45 ± 1.2
+|pH 7.5
+|-
+|44.4 ± 2.4
+|pH 8
 |-
 |}