Difference between revisions of "Transformation of AA to 15-HPETE"
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== Parameters == | == Parameters == | ||
| − | {|class="wikitable" | + | {|class="wikitable sortable" |
| − | + | |+ style="text-align: left;" | Michaelis-Menten Constants | |
| + | |- | ||
! Value | ! Value | ||
! Units | ! Units | ||
! Species | ! Species | ||
| + | ! Notes | ||
! Reference | ! Reference | ||
|- | |- | ||
| − | | | + | |3.70E-03 ± 3.00E-04 |
| − | | | + | |<math> mM </math> |
| − | | | + | |Human |
| − | | | + | |Epithelium |
| − | | B | + | |<ref name="Jacquot2008"> [http://www.ncbi.nlm.nih.gov/pubmed/18547056 Jacquot C. "Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases.'' Biochemistry. 2008 Jul 8;47(27):7295-303. doi: 10.1021/bi800308q. Epub 2008 Jun 12.]</ref> |
| + | |- | ||
| + | |5.00E-03 | ||
| + | |<math> mM </math> | ||
| + | |Human | ||
| + | |Reticulocyte | ||
| + | |<ref name="Jacquot2008b"> [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883171/ Jacquot C. "Synthesis of 11-Thialinoleic Acid and 14-Thialinoleic Acid, Inhibitors of Soybean and Human Lipoxygenases'' Org Biomol Chem. 2008 Nov 21; 6(22): 4242–4252.]</ref> | ||
| + | |- | ||
| + | |1.06E-02 | ||
| + | |<math> mM </math> | ||
| + | |Human | ||
| + | |Keratinocyte | ||
| + | |<ref name="Burrall1988"> [http://www.ncbi.nlm.nih.gov/pubmed/2459258 Burrall B. "Enzymatic properties of the 15-lipoxygenase of human cultured keratinocytes.'' J Invest Dermatol. 1988 Oct;91(4):294-7.]</ref> | ||
| + | |- | ||
| + | |1.17E-02 ± 9.00E-04 | ||
| + | |<math> mM </math> | ||
| + | |Human | ||
| + | | Wildtype 15-Lipoxygenase | ||
| + | |<ref name="Sloane1995"> [http://www.ncbi.nlm.nih.gov/pubmed/7479689 Sloane D. L. "Conversion of human 15-lipoxygenase to an efficient 12-lipoxygenase: the side-chain geometry of amino acids 417 and 418 determine positional specificity.'' Protein Eng. 1995 Mar;8(3):275-82..]</ref> | ||
| + | |- | ||
| + | |} | ||
| + | |||
| + | {|class="wikitable sortable" | ||
| + | |+ style="text-align: left;" | Enzyme Turnover Numbers | ||
| + | |- | ||
| + | ! Value | ||
| + | ! Units | ||
| + | ! Species | ||
| + | ! Notes | ||
| + | ! Reference | ||
| + | |- | ||
| + | |9.93 ± 0.28 | ||
| + | |<math> s^{-1} </math> | ||
| + | |Human | ||
| + | |Epithelium | ||
| + | |<ref name="Jacquot2008"> [http://www.ncbi.nlm.nih.gov/pubmed/18547056 Jacquot C. "Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases.'' Biochemistry. 2008 Jul 8;47(27):7295-303. doi: 10.1021/bi800308q. Epub 2008 Jun 12.]</ref> | ||
| + | |- | ||
|} | |} | ||
| + | |||
| + | == References == | ||
| + | <references/> | ||
== Related Reactions == | == Related Reactions == | ||
Revision as of 13:51, 8 April 2016
Contents
Reaction
Chemical equation
Rate equation
Parameters
| Value | Units | Species | Notes | Reference |
|---|---|---|---|---|
| 3.70E-03 ± 3.00E-04 | 
|
Human | Epithelium | [1] |
| 5.00E-03 |
|
Human | Reticulocyte | [2] |
| 1.06E-02 |
|
Human | Keratinocyte | [3] |
| 1.17E-02 ± 9.00E-04 |
|
Human | Wildtype 15-Lipoxygenase | [4] |
| Value | Units | Species | Notes | Reference |
|---|---|---|---|---|
| 9.93 ± 0.28 | Failed to parse (Cannot store math image on filesystem.): s^{-1} | Human | Epithelium | [1] |
References
- ↑ 1.0 1.1 Jacquot C. "Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases. Biochemistry. 2008 Jul 8;47(27):7295-303. doi: 10.1021/bi800308q. Epub 2008 Jun 12.
- ↑ Jacquot C. "Synthesis of 11-Thialinoleic Acid and 14-Thialinoleic Acid, Inhibitors of Soybean and Human Lipoxygenases Org Biomol Chem. 2008 Nov 21; 6(22): 4242–4252.
- ↑ Burrall B. "Enzymatic properties of the 15-lipoxygenase of human cultured keratinocytes. J Invest Dermatol. 1988 Oct;91(4):294-7.
- ↑ Sloane D. L. "Conversion of human 15-lipoxygenase to an efficient 12-lipoxygenase: the side-chain geometry of amino acids 417 and 418 determine positional specificity. Protein Eng. 1995 Mar;8(3):275-82..
