Transformation of AA to 12-HPETE

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Reaction

R179AA - HPETE12.jpg

Chemical equation

AA \rightleftharpoons PGH2

Rate equation

12-LOX Parameters

Michaelis-Menten Constants
Value Units Species Notes Reference
7.20E-03 mM Human Platelet [1]
8.00E-02 mM Human Platelet [2]
1.00E-02 mM Human Recombinant Histidine-Tagged Human Platelet 12-Lipoxygenase [3]
7.90E-03 ± 8.00E-04 mM Human Platelet 12-Lipoxygenase [4]
Enzyme Turnover Numbers
Value Units Species Notes Reference

References

  1. ↑ Lagarde M. "Subcellular localization and some properties of lipoxygenase activity in human blood platelets. Biochem J. 1984 Sep 1;222(2):495-500.
  2. ↑ Hada T. "Catalytic properties of human platelet 12-lipoxygenase as compared with the enzymes of other origins. Biochim Biophys Acta. 1991 Apr 24;1083(1):89-93.
  3. ↑ Chen X. S. "Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system. Eur J Biochem. 1993 Jun 15;214(3):845-52.
  4. ↑ Romano M. "Lipoxin synthase activity of human platelet 12-lipoxygenase. Biochem J. 1993 Nov 15;296 ( Pt 1):127-33.

Related Reactions

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