Transformation of 5-HPETE to LTA4
The leukotriene products of the 5-LOX pathway, are important in the inflammation process as they are well-known for the recruitment of infiltrating inflammatory species such as neutrophils and leukocytes (Serhan, Jain et al. 2003, Sadik, Sezin et al. 2013).
The 5-LOX enzyme requires the FLAP protein to be active in the cell, to produce 5-HETE and LTA4.
Contents
Reaction
Chemical equation
Rate equation
Parameters
| Value | Units | Species | Notes | Reference |
|---|---|---|---|---|
| (-86.007) | kcal/mol | Not stated | Estimated
Enzyme: 5-LOX Substrate: 5-HPETE Product: LTA4 pH: 7.3 ionic strength: 0.25 |
[1] |
