Transformation of 15-HPETE to 15-HETE

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15-HPETE is reduced by phospholipid hydroperoxide glutathione peroxidase (PHGPx) to the corresponding alcohol, 15-HETE (Suth01). 15-HETE and 12-HETE have reciprocal activity during inflammation, for example 15-HETE reduces the infiltration of inflammatory cells, meanwhile 12-HETE acts as an activator for infiltrating immune cells (Dowd, Kobza Black et al. 1985, Serhan, Jain et al. 2003).

Reaction

Chemical equation

$AA \rightleftharpoons PGH2$

Parameters

• See PHGPx parameters here.